Objective: We assessed changes in Motor Units (MU) and extent of MU loss using macro-electromyography (macro-EMG) and Motor Unit Number Estimation (MUNE). Methods: We applied these techniques to a sample of 61 Amyotrophic Lateral Sclerosis (ALS) patients basally (T0) and after 4 (T1), 8 (T2), and 12 (T3) months. Macro Motor Unit Potentials (macro-MUPs) were derived from Biceps Brachii (BB) muscle; MUNE was performed both in BB and Abductor Digiti Minimi (ADM) muscles of the same side. Results: Macro-MUPs area resulted in progressive increase at T1, T2, and T3 with respect to T0. Fiber density (FD) at T3 decreases a bit than at T2. Functioning MUS number decreased in both the muscles throughout the entire follow-up with respect to T0 and the rate of MU decrease was similar in both the muscles, but steeper distally. Conclusions and Significance: Macro-EMG increase and FD decrease suggest that a process of MU rearrangement begins to fall after 8 months of disease course. Combined use of macro-EMG and MUNE techniques in ALS patients allows to track over time changes in muscle MU features and number in face of progressive anterior horn cells death during disease's evolution. © 2011 Informa Healthcare USA, Inc.
Macro-EMG and MUNE changes in patients with amyotrophic lateral sclerosis: One-year follow up / F. Sartucci, G. Moscato, C. Rossi, M. Caleo, T. Bocci, L. Murri, F. Giannini, A. Rossi. - In: INTERNATIONAL JOURNAL OF NEUROSCIENCE. - ISSN 0020-7454. - 121:5(2011 May), pp. 257-266.
|Titolo:||Macro-EMG and MUNE changes in patients with amyotrophic lateral sclerosis: One-year follow up|
|Parole Chiave:||Amyotrophic lateral sclerosis; macro-EMG; MUNE; time changes|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
|Data di pubblicazione:||mag-2011|
|Data ahead of print / Data di stampa:||25-feb-2011|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3109/00207454.2010.550404|
|Appare nelle tipologie:||01 - Articolo su periodico|
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