Response-adaptive designs have been proposed in randomized clinical tri- als to achieve ethical advantages by using sequential accrual information collected during the trial to update probabilities of treatment assignments. We propose the use of a response adaptive design based on urn models in a simulation study on a randomized clinical trial on the efficacy of home enteral nutrition in cancer patients after major gastrointestinal surgery. We compare results with the adaptive design with those previously obtained with the non-adaptive approach.
A simulation study on the use of response-adaptive randomized designs / A.M. Paganoni, A. Ghiglietti, M.G. Scarale, R. Miceli, F. Ieva, L. Mariani, C. Gavazzi, V. Edefonti - In: Book of short Papers SIS 2018 of the 49th scientific meeting of the Italian Statistical Society / [a cura di] A. Abbruzzo, E. Brentari, M. Chiodi, D. Piacentino. - Prima edizione. - Palermo : Pearson, 2018. - ISBN 9788891910233. - pp. 1120-1125 (( Intervento presentato al 49. convegno Riunione Scientifica SIS tenutosi a Palermo nel 2018.
A simulation study on the use of response-adaptive randomized designs
A. Ghiglietti;M.G. Scarale;F. Ieva;L. Mariani;V. Edefonti
Ultimo
2018
Abstract
Response-adaptive designs have been proposed in randomized clinical tri- als to achieve ethical advantages by using sequential accrual information collected during the trial to update probabilities of treatment assignments. We propose the use of a response adaptive design based on urn models in a simulation study on a randomized clinical trial on the efficacy of home enteral nutrition in cancer patients after major gastrointestinal surgery. We compare results with the adaptive design with those previously obtained with the non-adaptive approach.File | Dimensione | Formato | |
---|---|---|---|
Atti_SIS_Palermo_2019.pdf
accesso aperto
Descrizione: Articolo principale con figura
Tipologia:
Publisher's version/PDF
Dimensione
419.54 kB
Formato
Adobe PDF
|
419.54 kB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.