A multicentric prospective study started in March '93 to describe both initial and acquired resistance of Mycobacterium Tuberculosis in Italian HIV+ patients (Pyrazinamide (pts.) to first line drugs: Rifampin (R), Isoniazid (I), Pyrazinamide (P), Ethambutol (E), Streptomycin (S). All tuberculosis (TB) cases diagnosed in HIV+ patients (pts.) were included, along with clinical-anamnestical data. Drug-susceptibility tests were performed centrally. Preliminary results indicate an overall low frequency of TB resistance to first line drugs: R=2%, P=4%, S=9%, I/E=none. However, a relevant nosocomial outbreak of multiple drug resistant (DR) TB was detected. This finding, along with some previous Italian reports of DR-TB clusters, may herald a further spread of DR-TB. Surveillance, therefore, is mandatory in Italy from now on.

Drug resistance of Mycobacterium tuberculosis strains isolated from HIV-infected Italian patients: preliminary report from a multicentric study / G. Angarano, D. Carbonara, D. Costa, M. Azzini, E. Mantia, G. Amendola, W. Caraccio, G. Scalise, A. Giacometti, F. Burzacchini, C. Piersimoni, F. Mazzotta, P. Blanc, S. Locaputo, S. Carbonara, M. Rollo, G. Pastore, S. Barbuti, A. Grimaldi, F. Chiodo, P. Costigliola, A. Nanetti, F. Gritti, A. Bini, C. Dipede, G. Carosi, A. Matteelli, G. Pinsi, T. Ferraro, A. Priamo, A. Foca, F. Ghinelli, M. Libanore, M. Rossi, F. Leoncini, P. Rogasi, G. Sterrantino, E. Tortoli, F. Giannelli, I. Errante, L. Caggese, A. Astolfi, A. Lazzarin, M. Moro, R. Vaiani, P. Mantellini, G. Besozzi, V. Penati, M. Moroni, A. Gori, L. Salvaggio, L. Tocalli, F. Milazzo, G. Vigevani, T. Quirino, C. Nardi, A. Cargnel, G. Dedivitiis, M. Piazza, A. Chirianni, M. Dabbraccio, P. Cadrobbi, F. Meneghetti, G. Bertiato, L. Ross, S. Pauluzzi, M. Pasticci, F. Bistoni, F. Alberici, P. Viale, M. Confalonieri, E. Cavatorta, G. Riccio, L. Santoriello, L. Bonazzi, M. Giudici, C. Morini, V. Giannini, P. Ghirga, E. Bordi, G. Panichi, S. Babudieri, S. Sarais, G. Fadda, L. Bagedda, P. Gioannini, A. Sinicco, L. Poncini, R. Milano, W. Grillone, F. Gaiottino, M. Soranzo, E. Nigra, M. Busso, V. Veglio, P. Panero, F. Delalla, G. Pellizzer, P. Fabris, M. Scagnelli, G. Antonucci, E. Girardi, G. Ippolito. - In: NEW MICROBIOLOGICA. - ISSN 1121-7138. - 18:1(1995), pp. 69-72.

Drug resistance of Mycobacterium tuberculosis strains isolated from HIV-infected Italian patients: preliminary report from a multicentric study

A. Gori;
1995

Abstract

A multicentric prospective study started in March '93 to describe both initial and acquired resistance of Mycobacterium Tuberculosis in Italian HIV+ patients (Pyrazinamide (pts.) to first line drugs: Rifampin (R), Isoniazid (I), Pyrazinamide (P), Ethambutol (E), Streptomycin (S). All tuberculosis (TB) cases diagnosed in HIV+ patients (pts.) were included, along with clinical-anamnestical data. Drug-susceptibility tests were performed centrally. Preliminary results indicate an overall low frequency of TB resistance to first line drugs: R=2%, P=4%, S=9%, I/E=none. However, a relevant nosocomial outbreak of multiple drug resistant (DR) TB was detected. This finding, along with some previous Italian reports of DR-TB clusters, may herald a further spread of DR-TB. Surveillance, therefore, is mandatory in Italy from now on.
HIV; tuberculosis; drug resistance
Settore MED/17 - Malattie Infettive
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/629255
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