In the present study, we describe an expansion of CD16(+) cells with a CD3(+) TcR gamma/delta(+) phenotype, in the presence of normal numbers of ''classic'' CD3(-)CD16(+) natural killer (NK) cells, in two patients with human immunodeficiency virus (HIV) infection in late stage. The NK activity of the two subjects was substantially higher then that of HIV+ subjects in the same stage of infection. A second evaluation of one of the patients showed levels of NK activity consistent with the clinical stage of HIV infection, concomitant with a remarkable reduction in the percentage of double-positive CD3/TcR gamma/delta cells. The number of CD16(+) cells also reached values comparable to those of the control group. In conclusion, we have identified a population of CD3(+)TcR gamma/delta(+)CD16(+) cells that have the capability to lyse an NK-sensitive target in two patients with unusually high levels of NK activity.

Transitory expansion of a CD3+TcR gamma/delta+CD16+ lymphocytic population in two patients with advanced human immunodeficiency virus infection and high levels of natural killer activity / G. Tambussi, V. Albarello, A. Gori, C. Bisson, A. Lazzarin. - In: AIDS RESEARCH AND HUMAN RETROVIRUSES. - ISSN 0889-2229. - 10:6(1994), pp. 711-715.

Transitory expansion of a CD3+TcR gamma/delta+CD16+ lymphocytic population in two patients with advanced human immunodeficiency virus infection and high levels of natural killer activity

A. Gori;
1994

Abstract

In the present study, we describe an expansion of CD16(+) cells with a CD3(+) TcR gamma/delta(+) phenotype, in the presence of normal numbers of ''classic'' CD3(-)CD16(+) natural killer (NK) cells, in two patients with human immunodeficiency virus (HIV) infection in late stage. The NK activity of the two subjects was substantially higher then that of HIV+ subjects in the same stage of infection. A second evaluation of one of the patients showed levels of NK activity consistent with the clinical stage of HIV infection, concomitant with a remarkable reduction in the percentage of double-positive CD3/TcR gamma/delta cells. The number of CD16(+) cells also reached values comparable to those of the control group. In conclusion, we have identified a population of CD3(+)TcR gamma/delta(+)CD16(+) cells that have the capability to lyse an NK-sensitive target in two patients with unusually high levels of NK activity.
T-cell receptor; activation; antigen; subset; interleukin-2; CD16+; CD3
Settore MED/17 - Malattie Infettive
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/629247
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