The gastrointestinal tract is colonized with a highly different population of bacterial, viral, ad fungal species; viruses are reported to be dominant. The composition of gut virome is closely related to dietary habits and surrounding environment. Host and their intestinal microbes live in a dynamic equilibrium and viruses stimulate a low degree of immune responses without causing symptoms (host tolerance). However, intestinal phages could lead to a rupture of eubiosis and may contribute to the shift from health to disease in humans and animals. Viral nucleic acids and other products of lysis of bacteria serve as pathogen-associated molecular patterns (PAMPs) and could trigger specific inflammatory modulations. At the same time, phages could elicit innate antiviral immune responses. Toll-like receptors (TLRs) operated as innate antiviral immune sensors and their activation triggers signaling cascades that lead to inflammatory response.
Beyond the gut bacterial microbiota : the gut virome / P. Columpsi, P. Sacchi, V. Zuccaro, S. Cima, C. Sarda, M. Mariani, A. Gori, R. Bruno. - In: JOURNAL OF MEDICAL VIROLOGY. - ISSN 0146-6615. - 88:9(2016), pp. 1467-1472.
|Titolo:||Beyond the gut bacterial microbiota : the gut virome|
|Parole Chiave:||Gut virome; Microbiota; Ultra deep sequencing; Virology; Infectious Diseases|
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
|Data di pubblicazione:||2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/jmv.24508|
|Appare nelle tipologie:||01 - Articolo su periodico|
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