Background: In clinical trials of recurrent and metastatic head and neck carcinoma, Argiris et al have identified prognostic factors for overall survival (OS) and progression-free survival (PFS), weight loss, Eastern Cooperative Oncology Group performance status (ECOG-PS), tumor primary site, tumor differentiation, prior radiotherapy, deriving a two-group prognostic classification. This study evaluates Argiris's classification in “field-practice” patients. Methods: The main analysis included 327 cases; a secondary analysis excluded 31 patients with oropharyngeal carcinoma (OPC) p16-positive and/or human papilloma virus (HPV)-positive. OS and PFS curves were estimated with the Kaplan-Meier method; multivariable Cox analyses were also performed. Results: In the full series, OS was significantly different in patients with 0-2 and ≥3 adverse features (median, 14 vs 10 months; P =.03). PFS was statistically different in the two groups (median, 7 vs 5 months; P =.02). At a multivariable analysis investigating additional prognostic features, site of relapse and disease-free interval were significant predictors of OS and PFS. Conclusion: The Argiris's model was confirmed in a “field-practice” population. Moreover, we found additional putative prognostic factors.

Prognostic factors in recurrent or metastatic squamous cell carcinoma of the head and neck / A. Mirabile, R. Miceli, R.G. Calderone, L. Locati, P. Bossi, C. Bergamini, R. Granata, F. Perrone, L. Mariani, L. Licitra. - In: HEAD & NECK. - ISSN 1043-3074. - (2019 Jan 16). [Epub ahead of print]

Prognostic factors in recurrent or metastatic squamous cell carcinoma of the head and neck

A. Mirabile;R.G. Calderone;L. Mariani;L. Licitra
2019-01-16

Abstract

Background: In clinical trials of recurrent and metastatic head and neck carcinoma, Argiris et al have identified prognostic factors for overall survival (OS) and progression-free survival (PFS), weight loss, Eastern Cooperative Oncology Group performance status (ECOG-PS), tumor primary site, tumor differentiation, prior radiotherapy, deriving a two-group prognostic classification. This study evaluates Argiris's classification in “field-practice” patients. Methods: The main analysis included 327 cases; a secondary analysis excluded 31 patients with oropharyngeal carcinoma (OPC) p16-positive and/or human papilloma virus (HPV)-positive. OS and PFS curves were estimated with the Kaplan-Meier method; multivariable Cox analyses were also performed. Results: In the full series, OS was significantly different in patients with 0-2 and ≥3 adverse features (median, 14 vs 10 months; P =.03). PFS was statistically different in the two groups (median, 7 vs 5 months; P =.02). At a multivariable analysis investigating additional prognostic features, site of relapse and disease-free interval were significant predictors of OS and PFS. Conclusion: The Argiris's model was confirmed in a “field-practice” population. Moreover, we found additional putative prognostic factors.
classification; head and neck cancer; prognosis; recurrence; squamous cell carcinoma; Otorhinolaryngology2734 Pathology and Forensic Medicine
Settore MED/06 - Oncologia Medica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/628526
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