Erectile dysfunction (ED) has been found to frequently precedes the onset of coronary artery disease (CAD), representing an early marker of subclinical vascular disease, included CAD. Its recognition is, therefore, a "window opportunity" to prevent a coronary event by aggressive treatment of cardiovascular risk factors. The artery size hypothesis (ASH) has been proposed as a putative mechanism to explain the relationship between ED and CAD. Since atherosclerosis is a systemic disorder all major vascular beds should be affected to the same extent. However, symptoms at different points in the system rarely become evident at the same time. This is likely the result of smaller vessels (i.e. the penile artery) being able to less well tolerate the same amount of plaque when compared with larger ones (i.e. the coronary artery). If true, ED will develop before CAD. We present a case in which ED developed after a coronary event yet before a coronary recurrence potentially representing a late marker of vascular progression. Reasons for this unusual sequence are discussed as they might still fit the ASH.
Clinical significance of erectile dysfunction developing after acute coronary event : exception to the rule or confirmation of the artery size hypothesis? / P. Montorsi, P.M. Ravagnani, C. Vlachopoulos. - In: ASIAN JOURNAL OF ANDROLOGY. - ISSN 1008-682X. - 17:1(2015), pp. 21-25.
|Titolo:||Clinical significance of erectile dysfunction developing after acute coronary event : exception to the rule or confirmation of the artery size hypothesis?|
|Parole Chiave:||artery size hypothesis; coronary artery disease; erectile dysfunction; Adrenergic beta-Antagonists; Arteries; Atherosclerosis; Coronary Artery Disease; Disease Progression; Erectile Dysfunction; Follow-Up Studies; Humans; Male; Middle Aged; Penis; Percutaneous Coronary Intervention; Recurrence; Treatment Outcome; Urology|
|Settore Scientifico Disciplinare:||Settore MED/11 - Malattie dell'Apparato Cardiovascolare|
|Data di pubblicazione:||2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.4103/1008-682X.139254|
|Appare nelle tipologie:||01 - Articolo su periodico|