The WHOEnd TBStrategy,endorsed bytheWorld Health Assemblyin May2014, hasthe ambitious goal ofendingtheglobal tuberculosis(TB) epidemic by2035, with targets of a95%decline in deaths duetoTB (compared with2015) and a90%reduction in incidence ofTB totencases/100,000 orlessand no TB-affected household experiencingcatastrophiccosts dueto TB. • Achieving thisgoalwill only bepossiblethrough the development and rapid uptake of new tools,including rapid point-of-care diagnostics,safeand shorter treatment of latent TBinfection anddisease, andan efficacious TB vaccine, combined with efficient health systems and careprovision, and actions on thesocialdeterminants of TB. • Research for TBeliminationrequires an intensification ofeffortsacross acontinuum fromfundamental research toclinical, epidemiological,implementation,health system, andsocialscience research. Enhancing research along the fullspectrum,from basic toimplementation,and strengtheningresearch capacity, particularly inlow- andmiddle-income countries severely affectedbythe TBepidemics,iscrucial for TBelimination. • The creation of aresearch-enabling environment thatfostersand rewards high-quality research requires abroad-based, concertedeffort bynational governments and international donors todevelopandpromoteTB research and research capacity at the country level and theeffective engagement of allstakeholders.

Translational Research for Tuberculosis Elimination : Priorities, Challenges, and Actions / C. Lienhardt, K. Lönnroth, D. Menzies, M. Balasegaram, J. Chakaya, F. Cobelens, J. Cohn, C.M. Denkinger, T.G. Evans, G. Källenius, G. Kaplan, A.M.V. Kumar, L. Matthiessen, C.S. Mgone, V. Mizrahi, Y. Mukadi, V.N. Nguyen, A. Nordström, C.F. Sizemore, M. Spigelman, S.B. Squire, S. Swaminathan, P.D. Van Helden, A. Zumla, K. Weyer, D. Weil, M. Raviglione. - In: PLOS MEDICINE. - ISSN 1549-1277. - 13:3(2016), pp. e1001965.1-e1001965.11.

Translational Research for Tuberculosis Elimination : Priorities, Challenges, and Actions

M. Raviglione
2016

Abstract

The WHOEnd TBStrategy,endorsed bytheWorld Health Assemblyin May2014, hasthe ambitious goal ofendingtheglobal tuberculosis(TB) epidemic by2035, with targets of a95%decline in deaths duetoTB (compared with2015) and a90%reduction in incidence ofTB totencases/100,000 orlessand no TB-affected household experiencingcatastrophiccosts dueto TB. • Achieving thisgoalwill only bepossiblethrough the development and rapid uptake of new tools,including rapid point-of-care diagnostics,safeand shorter treatment of latent TBinfection anddisease, andan efficacious TB vaccine, combined with efficient health systems and careprovision, and actions on thesocialdeterminants of TB. • Research for TBeliminationrequires an intensification ofeffortsacross acontinuum fromfundamental research toclinical, epidemiological,implementation,health system, andsocialscience research. Enhancing research along the fullspectrum,from basic toimplementation,and strengtheningresearch capacity, particularly inlow- andmiddle-income countries severely affectedbythe TBepidemics,iscrucial for TBelimination. • The creation of aresearch-enabling environment thatfostersand rewards high-quality research requires abroad-based, concertedeffort bynational governments and international donors todevelopandpromoteTB research and research capacity at the country level and theeffective engagement of allstakeholders.
Medicine (all)
Settore MED/17 - Malattie Infettive
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/626632
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