Trifluoromethylselenolated carbonyl compounds represent an emerging class with potential applications in several fields; however, a widespread use of such compound is hampered by the very limited number of strategies for their preparation. In this study we developed a method for the preparation of alpha-SeCF3 substituted carbonyl derivatives using an in situ generated electrophilic ClSeCF3 species. We also implemented an in-flow protocol to improve the safety features of the process.
Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions / E. Massolo, M. Pirola, S. Rossi, T. Benincori. - In: MOLECULES. - ISSN 1420-3049. - 24:4(2019 Feb 18), pp. 726.1-726.8.
Titolo: | Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions |
Autori: | MASSOLO, ELISABETTA (Primo) PIROLA, MARGHERITA (Secondo) |
Parole Chiave: | trifluoromethylselenolation; carbonyl compounds; selenium; fluorinated derivatives; flow chemistry |
Settore Scientifico Disciplinare: | Settore CHIM/06 - Chimica Organica |
Data di pubblicazione: | 18-feb-2019 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.3390/molecules24040726 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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