Trifluoromethylselenolated carbonyl compounds represent an emerging class with potential applications in several fields; however, a widespread use of such compound is hampered by the very limited number of strategies for their preparation. In this study we developed a method for the preparation of alpha-SeCF3 substituted carbonyl derivatives using an in situ generated electrophilic ClSeCF3 species. We also implemented an in-flow protocol to improve the safety features of the process.
Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions / E. Massolo, M. Pirola, S. Rossi, T. Benincori. - In: MOLECULES. - ISSN 1420-3049. - 24:4(2019 Feb 18), pp. 726.1-726.8.
|Titolo:||Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions|
MASSOLO, ELISABETTA (Primo)
PIROLA, MARGHERITA (Secondo)
ROSSI, SERGIO (Corresponding)
|Parole Chiave:||trifluoromethylselenolation; carbonyl compounds; selenium; fluorinated derivatives; flow chemistry|
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
|Data di pubblicazione:||18-feb-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/molecules24040726|
|Appare nelle tipologie:||01 - Articolo su periodico|