Non-canonical Notch signaling encompasses a wide range of cellular processes, diverging considerably from the established paradigm. It can dispense of ligand, proteolytic or nuclear activity. Non-canonical Notch signaling events have been studied mostly in the fruit fly Drosophila melanogaster, the organism in which Notch was identified first and a powerful model for understanding signaling outcomes. However, non-canonical events are ill-defined and their involvement in human physiology is not clear, hampering our understanding of diseases arising from Notch signaling alterations. At a time in which therapies based on specific targeting of Notch signaling are still an unfulfilled promise, detailed understanding of non-canonical Notch events might be key to devising more specific and less toxic pharmacologic options. Based on the blueprint of non-canonical signaling in Drosophila, here, we review and rationalize current evidence about non-canonical Notch signaling. Our effort might inform Notch biologists developing new research avenues and clinicians seeking future treatment of Notch-dependent diseases.

Mechanisms of non-canonical signaling in health and disease: Diversity to take therapy up a notch? / V. Alfred, T. Vaccari (ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY). - In: Molecular Mechanisms of Notch Signaling / [a cura di] T. Borggrefe, B.D. Giaimo. - [s.l] : Springer, 2018. - ISBN 9783319895116. - pp. 187-204 [10.1007/978-3-319-89512-3_9]

Mechanisms of non-canonical signaling in health and disease: Diversity to take therapy up a notch?

V. Alfred
Primo
;
T. Vaccari
Ultimo
2018

Abstract

Non-canonical Notch signaling encompasses a wide range of cellular processes, diverging considerably from the established paradigm. It can dispense of ligand, proteolytic or nuclear activity. Non-canonical Notch signaling events have been studied mostly in the fruit fly Drosophila melanogaster, the organism in which Notch was identified first and a powerful model for understanding signaling outcomes. However, non-canonical events are ill-defined and their involvement in human physiology is not clear, hampering our understanding of diseases arising from Notch signaling alterations. At a time in which therapies based on specific targeting of Notch signaling are still an unfulfilled promise, detailed understanding of non-canonical Notch events might be key to devising more specific and less toxic pharmacologic options. Based on the blueprint of non-canonical signaling in Drosophila, here, we review and rationalize current evidence about non-canonical Notch signaling. Our effort might inform Notch biologists developing new research avenues and clinicians seeking future treatment of Notch-dependent diseases.
Drosophila melanogaster; Ligand-independent signaling; MTOR/Akt signaling; NF-κB signaling; Non-canonical activation; Notch signaling; Wnt/β-catenin signaling; Biochemistry, Genetics and Molecular Biology (all)
Settore BIO/13 - Biologia Applicata
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/625377
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