The link diet-cognitive function/dementia has been largely investigated in observational studies; however, there was a lack of evidence from randomized clinical trials (RCTs) on the prevention of late-life cognitive disorders though dietary intervention in cognitively healthy older adults. In the present article, we systematically reviewed RCTs published in the last four years (2014-2017) exploring nutritional intervention efficacy in preventing the onset of late-life cognitive disorders and dementia in cognitively healthy subjects aged 60 years and older using different levels of investigation (i.e., dietary pattern changes/medical food/nutraceutical supplementation/multidomain approach and dietary macro- and micronutrient approaches) as well as possible underlying mechanisms of nutritional prevention. From the 35 included RCTs, there was moderate evidence that intervention through dietary pattern changes, medical food/nutraceutical supplementation, and multidomain approach improved specific cognitive domains or cognitive-related blood biomarkers. There was high evidence that protein supplementation improved specific cognitive domains or functional status in prefrail older adults without effect.
Nutritional Intervention as a Preventive Approach for Cognitive-Related Outcomes in Cognitively Healthy Older Adults : a Systematic Review / V. Solfrizzi, P. Agosti, M. Lozupone, C. Custodero, A. Schilardi, V. Valiani, R. Sardone, V. Dibello, L. Di Lena, A. Lamanna, R. Stallone, A. Bellomo, A. Greco, A. Daniele, D. Seripa, C. Sabbà, G. Logroscino, F. Panza. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 64:suppl. 1(2018), pp. S229-S254.
|Titolo:||Nutritional Intervention as a Preventive Approach for Cognitive-Related Outcomes in Cognitively Healthy Older Adults : a Systematic Review|
|Parole Chiave:||Alzheimer's disease; dementia; dietary pattern; healthy diet; macronutrients; medical food; Mediterranean diet; micronutrients; mild cognitive impairment; nutraceuticals; prevention; Neuroscience (all); Clinical Psychology; Geriatrics and Gerontology; Psychiatry and Mental Health|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
Settore MED/26 - Neurologia
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
|Data di pubblicazione:||2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3233/JAD-179940|
|Appare nelle tipologie:||01 - Articolo su periodico|