Transoral CO2 laser treatment for Tis-T3 glottic cancer: The University of Brescia experience on 595 patients

Background. Transoral CO2 laser surgery has been accepted as a valuable therapeutic option for glottic cancer. Methods. This was a retrospective analysis of 595 patients. Five-year overall and disease-specific survivals, local control with laser, locoregional, regional control, and organ preservation rates were calculated. The impact of different variables was calculated by univariate analysis. Results. Overall, disease-specific and disease-free survivals, local control with laser, locoregional, regional control, and organ preservation rates were 87.5%, 99%, 81.3%, 92.7%, 98.9%, 98.2%, and 97.1%, respectively. Univariate analysis showed a significant impact of pT category on local control with laser, organ preservation, locoregional and regional control, of endoscopic re-treatment for positive deep surgical margins on local control with laser and organ preservation, and recurrence after endoscopic re-treatment on local control with laser and organ preservation. Conclusion. This series confirms the good oncologic outcomes of endoscopic laser surgery for Tis, T1, and selected T2 and T3 glottic tumors.