The aim of this study was to define the clinical impact of Herpes simplex virus-1 (HSV-1) DNA detection in the low respiratory tract of hospitalized patients. Forty-nine patients admitted to the University Hospital Tor Vergata, Rome, Italy, from May 2013 to June 2014, were analysed. Inclusion criteria were the presence or absence of HSV-1 DNA in clinical routine bronchoalveolar lavage (BAL) fluid specimens. Nineteen individuals were positive (cases) and 30 negative (controls) for the presence of HSV-1 DNA. The two groups were matched for age, gender and month of BAL collection. Cases and controls differed significantly according to length of stay in hospital (p=0.027), ICU transfer (p=0.02), disease severity (p=0.003), death (p=0.009), haematological and blood chemistry tests. Among cases, survivors and deceased patients differed significantly regarding ICU transfer (p=0.0001), mechanical ventilation (p=0.0048), disease severity (p=0.028) and risk of death (p=0.013). A trend towards higher HSV-1 loads was observed in the cases who died. These results suggest that detection of HSV-1 DNA in BAL fluid specimens is a marker of disease severity and poor outcome. Further prospective studies are necessary to deepen the clinical significance of HSV-1 DNA detection in the lower respiratory tract of hospitalized patients.
Clinical features and outcome of hospitalized patients with HSV-1 DNA in the lower respiratory tract / F. Pica, M. Ciotti, M. Maurici, C. Buè, P. Nardi, G. Lucà, G. Moroni, P. Rogliani, C.F. Perno, A. Volpi. - In: NEW MICROBIOLOGICA. - ISSN 1121-7138. - 40:2(2017 Apr), pp. 107-112.
|Titolo:||Clinical features and outcome of hospitalized patients with HSV-1 DNA in the lower respiratory tract|
|Parole Chiave:||BAL fluids; Clinical outcome; HSV-1; Hospitalized patients; Viral load; Adolescent; Adult; Aged; Aged, 80 and over; Bronchoalveolar Lavage Fluid; DNA, Viral; Female; Herpesvirus 1, Human; Humans; Inpatients; Male; Middle Aged; Young Adult|
|Settore Scientifico Disciplinare:||Settore MED/07 - Microbiologia e Microbiologia Clinica|
|Data di pubblicazione:||apr-2017|
|Appare nelle tipologie:||01 - Articolo su periodico|