Incidenza e fattori di rischio della colelitiasi in pazienti affetti da morbo di Crohn e da colite ulcerosa. Uno studio prospettico di coorte

Crohn s disease (CD) has been associated with higher prevalence of gallstone disease (GD). Aim of this prospective study was to evaluate the risk of developing GD in a defined cohort of CD and Ulcerative colitis (UC) patients. We prospectively evaluated a cohort of 600 consecutive patients with IBD (415 CD, 185 UC) as compared with 600 age, sex and BMI matched GD-free controls. Multivariate analysis was used to discriminate among the impact of different variables on the risk of developing GD. The risk of developing GD was 2,09 in CD patients and 1,33 in UC patients as compared to matched controls. On logistic regression analysis, ileo-colonic site of CD, disease duration, clinical recurrences, ileal resection, length of hospitalisation were independently associated with GD in CD. Our data show that CD patients have a double risk of developing GD compared with age, sex and BMI matched healthy controls, whereas the risk of GD in UC is similar to the general population. Site of disease, surgery, extent of ileal resections but also number of clinical recurrences, frequency and duration of hospitalisations are the most important independent risk factors for GD.