Histone deacetylases (HDACs) are modification enzymes that regulate a plethora of biological processes. HDAC1, a crucial epigenetic modifier, is deregulated in cancer and subjected to a variety of post-translational modifications. Here, we describe the generation of a new monoclonal antibody that specifically recognizes a novel highly dynamic prophase phosphorylation of serine 406-HDAC1, providing a powerful tool for detecting early mitotic cells.
A monoclonal antibody specific for prophase phosphorylation of histone deacetylase 1 : a readout for early mitotic cells / C. Segré, S. Senese, S. Loponte, S. Santaguida, P. Soffientini, G. Grigorean, M. Cinquanta, G. Ossolengo, C. Seiser, S. Chiocca. - In: MABS. - ISSN 1942-0862. - 8:1(2016), pp. 37-42. [10.1080/19420862.2015.1098795]
A monoclonal antibody specific for prophase phosphorylation of histone deacetylase 1 : a readout for early mitotic cells
S. Santaguida;
2016
Abstract
Histone deacetylases (HDACs) are modification enzymes that regulate a plethora of biological processes. HDAC1, a crucial epigenetic modifier, is deregulated in cancer and subjected to a variety of post-translational modifications. Here, we describe the generation of a new monoclonal antibody that specifically recognizes a novel highly dynamic prophase phosphorylation of serine 406-HDAC1, providing a powerful tool for detecting early mitotic cells.
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
