On the basis of contradictory findings on the rewarding effects of Delta9-tetrahydrocannabinol (Delta9-THC) in laboratory animals, the effect of the compound on conditioned place preference and intracerebroventricular (i.c.v.) self-administration in a free-choice procedure, using a wide range of doses (0.015-6 mg/kg for conditioned place preference test and 0.01-1 microg/2 microl/infusion for i.c.v. self-administration), was studied in Wistar rats. The present results showed that Delta9-THC induced reward in both tests, but only at the lowest tested doses (0.075-0.75 mg/kg i.p. for conditioned place preference test and 0.01-0.02 microg/infusion for i.c.v. self-administration). This effect was fully antagonised by i.p. pretreatment with the cannabinoid CB1 receptor antagonist, SR 141716A [N-piperidino-5-(4-chlorophenyl)1-(2,4-dichlorophenyl)-4 methyl pyrazole 3-carboxamide] (0.25-1 mg/kg), and the opiate receptor antagonist, naloxone (0.5-2 mg/kg), suggesting the involvement of both endocannabinoid and opioid systems. In conclusion, these findings demonstrate, for the first time, that low doses of Delta9-THC can act as an effective reinforcer in Wistar rats providing a reliable animal model of human marijuana abuse.
|Titolo:||Delta9-tetrahydrocannabinol-induced conditioned place preference and intracerebroventricular self-administration in rats|
|Autori interni:||SALA, MARIAELVINA (Ultimo)|
PEGORINI, SIMONA (Penultimo)
BRAIDA, DANIELA (Primo)
IOSUE', STEFANIA (Secondo)
|Parole Chiave:||Δ 9-THC; Conditioned place preference; i.c.v. self-administration|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||3-dic-2004|
|Digital Object Identifier (DOI):||10.1016/j.ejphar.2004.10.043|
|Appare nelle tipologie:||01 - Articolo su periodico|
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