Background: Oral tongue/floor of mouth squamous cell carcinoma (OTFMSCC) with a depth of invasion (DOI) > 10 mm involves extrinsic muscles and lingual neurovascular/lymphatic bundles. “Compartmental” hemiglossopelvectomy (CHGP) was developed to improve loco-regional control by “en bloc” removal of tumor and its pathways of spread. Methods: We conducted a retrospective observational study on 45 CHGPs performed at a single institution for OTFMSCC with a DOI > 10 mm at CT/MR. Group A (n = 35) included naïve patients, and group B (n = 10) recurrent cancers. We evaluated 2-year overall survival (OS), disease-free survival (DFS), local control (LC), and loco-regional control (LRC). Results: Two-year OS, DFS, LC, and LRC were 80%, 91%, 100%, and 94% for group A, and 27%, 26%, 67%, and 36% for group B, respectively. Salvage surgery and positive margins were significantly associated with worse prognosis. Conclusion: CHGP is a reliable oncologic approach in primary surgery for advanced OTFMSCC. In recurrent cancers, survival remains poor.
Compartmental surgery for oral tongue and floor of the mouth cancer : oncologic outcomes / C. Piazza, A. Grammatica, N. Montalto, A. Paderno, F. Del Bon, P. Nicolai. - In: HEAD & NECK. - ISSN 1043-3074. - 41:1(2019 Jan), pp. 110-115.
|Titolo:||Compartmental surgery for oral tongue and floor of the mouth cancer : oncologic outcomes|
PIAZZA, CESARE (Corresponding)
|Parole Chiave:||compartmental surgery; floor of mouth; hemiglossopelvectomy; oral tongue; squamous cell carcinoma; Otorhinolaryngology; 2734; Pathology and Forensic Medicine|
|Settore Scientifico Disciplinare:||Settore MED/31 - Otorinolaringoiatria|
|Data di pubblicazione:||gen-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/hed.25480|
|Appare nelle tipologie:||01 - Articolo su periodico|