Objectives: to screen anti-HIV agents from telomerase restrictors(TRs); Method: Selection of the maximum concentration of telomerase restrictor with minimum toxicity by means of MTT proliferation determination, and screening of anti-HIV agents by means of determining CEM-GFP fluorescence with FACS and through INNOTEST P24 HIV Antigen mAb ELISA. Results: Two telomerase restrictors were demonstrated to effectively restrict the proliferation of HIV. Conclusion: Telomerase restrictors(TR) might be the source for screening anti-HIV agents.
Telomerase restrictors might be a novel source for screening anti-HIV agents / X. Yu, J. Wang, C. De Giuli Morghen, A. Radaelli, C. Zanotto, P. Beggio - In: ICBBE 2007 : the 1. International Conference on Bioinformatics and Biomedical Engineering : 6-8 July 2007New York : IEEE, 2007. - ISBN 1-4244-1120-3. - pp. 88-91 (( Intervento presentato al 1. convegno International Conference on Bioinformatics and Biomedical Engineering tenutosi a Wuhan (China) nel 2007 [10.1109/ICBBE.2007.26].
Telomerase restrictors might be a novel source for screening anti-HIV agents
C. De Giuli Morghen;A. Radaelli;C. ZanottoPenultimo
;P. BeggioUltimo
2007
Abstract
Objectives: to screen anti-HIV agents from telomerase restrictors(TRs); Method: Selection of the maximum concentration of telomerase restrictor with minimum toxicity by means of MTT proliferation determination, and screening of anti-HIV agents by means of determining CEM-GFP fluorescence with FACS and through INNOTEST P24 HIV Antigen mAb ELISA. Results: Two telomerase restrictors were demonstrated to effectively restrict the proliferation of HIV. Conclusion: Telomerase restrictors(TR) might be the source for screening anti-HIV agents.
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