This chapter introduces the study of the major evolutionary forces operating in large gene families. The reconstruction of duplication history and phylogenetic analysis provide an interpretative framework of the evolution of multigene families. We present here two case studies, the first coming from Eukaryotes (chemokine receptors) and the second from Prokaryotes (TIM barrel proteins), showing how functional and structural constraints have shaped gene duplication events.
Phylogenetics and computational biology of multigene families / P. Lio', M. Brilli, R. Fani (BIOLOGICAL AND MEDICAL PHYSICS, BIOMEDICAL ENGINEERING). - In: Structural approaches to sequence evolution : Molecules, Networks, Populations / [a cura di] U. Bastolla, M. Porto, H.E. Roman, M. Vendruscolo. - [s.l] : Springer-Verlag, 2007. - ISBN 3-540-35305-4. - pp. 191-205 [10.1007/978-3-540-35306-5_9]
Phylogenetics and computational biology of multigene families
M. BrilliSecondo
;
2007
Abstract
This chapter introduces the study of the major evolutionary forces operating in large gene families. The reconstruction of duplication history and phylogenetic analysis provide an interpretative framework of the evolution of multigene families. We present here two case studies, the first coming from Eukaryotes (chemokine receptors) and the second from Prokaryotes (TIM barrel proteins), showing how functional and structural constraints have shaped gene duplication events.
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