Radioactive solutions of 177g,mLuIIICl3 are used for labeling organic compounds for metabolic radiotherapy and radioimmunotherapy. The labeling process involves Lu in III oxidation state, so the presence of other stable impurities in the same oxidation state could result in an isomorphous dilution of radioactive 177gLu. Samples of 177gLuCl3 were analyzed to quantify the chemical impurities with a special regard for trivalent elements with instrumental neutron activation analysis (INAA), carried out in the research nuclear reactor TRIGA MARK II (GA, USA) of the Università degli Studi di Pavia, and electrothermal atomic absorption spectroscopy (ET-AAS) (Varian, USA) at LASA.

Determination of chemical purity and specific activity of 177g,mLuCl3 by INAA and ET-AAS / F. Groppi, E. Persico, E. Quartapelle Procopio, M. Gallorini, L. Bergamaschi, M.C. Cantone. - In: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY. - ISSN 0236-5731. - 278:3(2008 Dec), pp. 595-598.

Determination of chemical purity and specific activity of 177g,mLuCl3 by INAA and ET-AAS

F. Groppi
Primo
;
E. Persico
Secondo
;
E. Quartapelle Procopio;M.C. Cantone
Ultimo
2008-12

Abstract

Radioactive solutions of 177g,mLuIIICl3 are used for labeling organic compounds for metabolic radiotherapy and radioimmunotherapy. The labeling process involves Lu in III oxidation state, so the presence of other stable impurities in the same oxidation state could result in an isomorphous dilution of radioactive 177gLu. Samples of 177gLuCl3 were analyzed to quantify the chemical impurities with a special regard for trivalent elements with instrumental neutron activation analysis (INAA), carried out in the research nuclear reactor TRIGA MARK II (GA, USA) of the Università degli Studi di Pavia, and electrothermal atomic absorption spectroscopy (ET-AAS) (Varian, USA) at LASA.
Luthetium-177g ; metabolic radiotherapy ; quality control test
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
http://www.springerlink.com.pros.lib.unimi.it/content/c2727729854v1612/fulltext.pdf
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/62110
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact