We focused our interest on senescent human-derived fibroblasts in the progression of prostate cancer. Hypoxic senescent fibroblasts promote prostate cancer aggressiveness by inducing epithelial to mesenchymal transition (EMT) and by secreting energy-rich compounds to support cancer cell growth. Hypoxic senescent fibroblasts additionally increase: i) the recruitment of monocytes and their M2-macrophage polarization, ii) the recruitment of bone marrow-derived endothelial precursor cells, facilitating their vasculogenic ability and iii) capillary morphogenesis, proliferation and invasion of human mature endothelial cells. In addition, we highlight that overexpression of the hypoxia-induced miR-210 in young fibroblasts increases their senescence-associated features and converts them into cancer associated fibroblast (CAF)-like cells, able to promote cancer cells EMT, to support angiogenesis and to recruit endothelial precursor cells and monocytes/macrophages.
Senescent stroma promotes prostate cancer progression : the role of miR-210 / M. Taddei, L. Cavallini, G. Comito, E. Giannoni, M. Folini, A. Marini, P. Gandellini, A. Morandi, G. Pintus, M. Raspollini, N. Zaffaroni, P. Chiarugi. - In: MOLECULAR ONCOLOGY. - ISSN 1574-7891. - 8:8(2014), pp. 1729-1746.
|Titolo:||Senescent stroma promotes prostate cancer progression : the role of miR-210|
|Parole Chiave:||Senescence; Prostate cancer; Tumor microenvironment; miR-210|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.molonc.2014.07.009|
|Appare nelle tipologie:||01 - Articolo su periodico|