Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angiogenesis and metastasis. In this view, the plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. This narrative review aims to provide an updated overview on the bioactive phytochemicals exhibiting a promising potential as adjuvants in conventional anticancer therapies, with emphasis on antiangiogenic and antimetastatic activities.

Phytotherapeutics in cancer invasion and metastasis / B. Salehi, P. Zucca, M. Sharifi-Rad, R. Pezzani, S. Rajabi, W.N. Setzer, E.M. Varoni, M. Iriti, F. Kobarfard, J. Sharifi-Rad. - In: PHYTOTHERAPY RESEARCH. - ISSN 0951-418X. - 32:8(2018), pp. 1425-1449.

Phytotherapeutics in cancer invasion and metastasis

E.M. Varoni;M. Iriti;
2018

Abstract

Cancer is a multifactorial disease, and therefore, a multitarget approach is needed to face the complex cancer biology, based on the combined use of different natural and synthetic anticancer agents able to target synergistically multiple signaling pathways involved in carcinogenesis, including angiogenesis and metastasis. In this view, the plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. This narrative review aims to provide an updated overview on the bioactive phytochemicals exhibiting a promising potential as adjuvants in conventional anticancer therapies, with emphasis on antiangiogenic and antimetastatic activities.
adjuvant therapy; anticancer drugs; cancer chemoprevention; chemotherapy; phytochemicals; plant products; Animals; Antineoplastic Agents, Phytogenic; Humans; Neoplasms; Phytochemicals; Plants; Signal Transduction; Phytotherapy; Pharmacology
Settore MED/28 - Malattie Odontostomatologiche
Settore AGR/12 - Patologia Vegetale
Article (author)
File in questo prodotto:
File Dimensione Formato  
Salehi_et_al-2018-Phytotherapy_Research.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 488.36 kB
Formato Adobe PDF
488.36 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/619786
Citazioni
  • ???jsp.display-item.citation.pmc??? 21
  • Scopus 85
  • ???jsp.display-item.citation.isi??? 74
social impact