Background: The plant kingdom represents an unlimited source of phytotherapeutics with promising perspectives in the field of anticancer drug discovery. Purpose: In this view, epithelial-mesenchymal transition (EMT) represents a novel and major target in anticancer therapy. Therefore, this narrative review aims to provide an updated overview on the bioactive phytochemicals with anti-EMT activity. Conclusion: Among the plant products reviewed, phenylpropanoids were the most investigated at preclinical phase, thus exhibiting a promising potential as anticancer drugs, though an evidence-based clinical efficacy is still lacking.
|Titolo:||Epithelial-mesenchymal transition as a target for botanicals in cancer metastasis|
|Parole Chiave:||Alkaloids; Anticancer phytotherapeutics; Bioactive phytochemicals; Chemoprevention; Isoprenoids; Phenylpropanoids; Molecular Medicine; Pharmacology; 3003; Drug Discovery; 3003; Pharmaceutical Science; Complementary and Alternative Medicine; 2708; Dermatology|
|Settore Scientifico Disciplinare:||Settore MED/28 - Malattie Odontostomatologiche|
Settore AGR/12 - Patologia Vegetale
|Data di pubblicazione:||1-mar-2019|
|Digital Object Identifier (DOI):||10.1016/j.phymed.2018.07.001|
|Appare nelle tipologie:||01 - Articolo su periodico|