Understanding the molecular/cellular underpinnings of diffuse malignant peritoneal mesothelioma (DMPM), a fatal malignancy with limited therapeutic options, is of utmost importance for the fruitful management of the disease. In this context, we previously found that telomerase activity (TA), which accounts for the limitless proliferative potential of cancer cells, is prognostic for disease relapse and cancer-related death in DMPM patients. Consequently, the identification of factors involved in telomerase activation/regulation may pave the way towards the development of novel therapeutic interventions for the disease. Here, the capability of miR-380-5p, a microRNA negligibly expressed in telomerase-positive DMPM clinical specimens, to interfere with telomerase-mediated telomere maintenance and, hence, with cancer cell growth was assessed on preclinical models of DMPM.
miR-380-5p-mediated repression of TEP1 and TSPYL5 interferes with telomerase activity and favours the emergence of an "ALT-like" phenotype in diffuse malignant peritoneal mesothelioma cells / G. Cimino-Reale, P. Gandellini, F. Santambrogio, M. Recagni, N. Zaffaroni, M. Folini. - In: JOURNAL OF HEMATOLOGY & ONCOLOGY. - ISSN 1756-8722. - 10:1(2017), pp. 140.1-140.14.
|Titolo:||miR-380-5p-mediated repression of TEP1 and TSPYL5 interferes with telomerase activity and favours the emergence of an "ALT-like" phenotype in diffuse malignant peritoneal mesothelioma cells|
|Parole Chiave:||Alternative lengthening of telomeres; Diffuse malignant peritoneal mesothelioma; Telomerase associated protein 1; Telomere maintenance mechanisms; Testis-specific protein, Y-encoded-like 5; miRNA; Carrier Proteins; Cell Proliferation; Humans; Lung Neoplasms; Mesothelioma; MicroRNAs; Nuclear Proteins; Phenotype; Prognosis; Telomerase; Transfection|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1186/s13045-017-0510-3|
|Appare nelle tipologie:||01 - Articolo su periodico|
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