Understanding stem cell commitment and differentiation is a critical step towards clinical translation of cell therapies. In past few years, several cell types have been characterized and transplanted in animal models for different diseased tissues, eligible for a cell-mediated regeneration. Skeletal muscle damage is a challenge for cell- and gene-based therapeutical approaches, given the unique architecture of the tissue and the clinical relevance of acute damages or dystrophies. In this review, we will consider the regenerative potential of embryonic and somatic stem cells and the outcomes achieved on their transplantation into animal models for muscular dystrophy or acute muscle impairment.
Cell therapy strategies and improvements for muscular dystrophy / M. Quattrocelli, M. Cassano, S. Crippa, I. Perini, M. Sampaolesi. - In: CELL DEATH AND DIFFERENTIATION. - ISSN 1350-9047. - 17:8(2010 Aug), pp. 1222-1229.
|Titolo:||Cell therapy strategies and improvements for muscular dystrophy|
|Parole Chiave:||muscular dystrophy; animal models; cell therapy; stem cells|
|Settore Scientifico Disciplinare:||Settore BIO/17 - Istologia|
|Data di pubblicazione:||ago-2010|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1038/cdd.2009.160|
|Appare nelle tipologie:||01 - Articolo su periodico|