Silk fibroin (SF) is the inner component of the silk fiber spun by Bombyx mori silkworm. It is considered a valuable material for biotechnology and biomedical applications due to its unique properties including biocompatibility, oxygen and water vapor permeability, biodegradability, and minimal inflammatory reaction. Sericin, which constitutes the outer layer of the fiber, was recently studied by several authors who underlined its antioxidant, antibacterial and anti-inflammatory properties, its protective action for serum deprived cells, being moreover considered a triggering molecule for apatite deposition. Fibroin and sericin can be processed to obtain powders, films, gels, filaments, etc., so making different materials that can tailored to the requirements of the specific application. These processes induce structural transitions and morphological changes that have a great influence on the physical and biological properties of the resulting materials. In this work two different SF-based hydrogels (100% SF and 90/10SF-Ser) and a pure fibroin sponge were compared in an in vivo critical size defect study in order to evaluate their bone regeneration capability.
Silk protein-based scaffolds for bone tissue engineering : an in vivo study / A. Addis, M. Campagnol, A. Motta, C. Migliaresi - In: FELASA-ICLAS Joint Meeting 2007 : Abstract BookS.l. : s.n., 2007 Jun 14. (( Intervento presentato al 10 FELASA, 14 ICLAS. convegno FELASA-ICLAS Joint Meeting tenutosi a Cernobbio (CO) nel 2007.
Silk protein-based scaffolds for bone tissue engineering : an in vivo study
A. AddisPrimo
;M. CampagnolSecondo
;
2007
Abstract
Silk fibroin (SF) is the inner component of the silk fiber spun by Bombyx mori silkworm. It is considered a valuable material for biotechnology and biomedical applications due to its unique properties including biocompatibility, oxygen and water vapor permeability, biodegradability, and minimal inflammatory reaction. Sericin, which constitutes the outer layer of the fiber, was recently studied by several authors who underlined its antioxidant, antibacterial and anti-inflammatory properties, its protective action for serum deprived cells, being moreover considered a triggering molecule for apatite deposition. Fibroin and sericin can be processed to obtain powders, films, gels, filaments, etc., so making different materials that can tailored to the requirements of the specific application. These processes induce structural transitions and morphological changes that have a great influence on the physical and biological properties of the resulting materials. In this work two different SF-based hydrogels (100% SF and 90/10SF-Ser) and a pure fibroin sponge were compared in an in vivo critical size defect study in order to evaluate their bone regeneration capability.Pubblicazioni consigliate
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