OBJECTIVES: We sought to investigate the echocardiographic myocardial performance index (MPI) to assess post-resuscitation myocardial function following electrically and ischemically induced ventricular fibrillation (VF). MATERIALS AND METHODS: VF was induced in fourteen anesthetized pigs weighing 38+/-4 kg. VF was induced electrically in seven animals and ischemically, following transient occlusion of the left anterior descending coronary artery (LAD), in the remaining seven animals. VF was untreated for 7 min after which CPR, including precordial compression and mechanical ventilation was begun. Defibrillation was attempted after 5 min of CPR. MPI, ejection fraction (EF) and fractional area change (FAC) were measured hourly during the following 4 h interval post-resuscitation. RESULTS: Five of seven animals were resuscitated in the electrically induced VF group, and four of seven animals in the ischemically induced VF group. No difference in EF and FAC were observed between the two groups. The MPI, however, was significantly greater at 60 min and 120 min post-resuscitation in animals after ischemically induced VF (p<0.05). CONCLUSION: In this model, left ventricular (LV) MPI was a more sensitive and useful quantitative parameter to assess the LV function than the EF and FAC measurements used routinely. MPI measurements indicated that post-resuscitation myocardial dysfunction may be more severe after ischemically induced VF compared to the electrically induced VF.

Myocardial performance index following electrically induced or ischemically induced cardiac arrest / T. Xu, W. Tang, G. Ristagno, S. Sun, H. Wang, M. Weil. - In: RESUSCITATION. - ISSN 0300-9572. - 76:1(2008), pp. 103-107. [10.1016/j.resuscitation.2007.06.004]

Myocardial performance index following electrically induced or ischemically induced cardiac arrest

G. Ristagno;
2008

Abstract

OBJECTIVES: We sought to investigate the echocardiographic myocardial performance index (MPI) to assess post-resuscitation myocardial function following electrically and ischemically induced ventricular fibrillation (VF). MATERIALS AND METHODS: VF was induced in fourteen anesthetized pigs weighing 38+/-4 kg. VF was induced electrically in seven animals and ischemically, following transient occlusion of the left anterior descending coronary artery (LAD), in the remaining seven animals. VF was untreated for 7 min after which CPR, including precordial compression and mechanical ventilation was begun. Defibrillation was attempted after 5 min of CPR. MPI, ejection fraction (EF) and fractional area change (FAC) were measured hourly during the following 4 h interval post-resuscitation. RESULTS: Five of seven animals were resuscitated in the electrically induced VF group, and four of seven animals in the ischemically induced VF group. No difference in EF and FAC were observed between the two groups. The MPI, however, was significantly greater at 60 min and 120 min post-resuscitation in animals after ischemically induced VF (p<0.05). CONCLUSION: In this model, left ventricular (LV) MPI was a more sensitive and useful quantitative parameter to assess the LV function than the EF and FAC measurements used routinely. MPI measurements indicated that post-resuscitation myocardial dysfunction may be more severe after ischemically induced VF compared to the electrically induced VF.
cardiopulmonary resuscitation; ventricular fibrillation; echocardiography; myocardial performance index
Settore MED/41 - Anestesiologia
Article (author)
File in questo prodotto:
File Dimensione Formato  
Resuscitation2008_MPI.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 152.1 kB
Formato Adobe PDF
152.1 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/618346
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 16
  • ???jsp.display-item.citation.isi??? 14
social impact