The inside back cover picture shows the ability of dendrimeric amino‐ and, in a much more efficient way, guanidinoneomycin‐PAMAM vehicles to promote the cellular uptake of high‐molecular‐weight biologicals, such as enzymes or proteins. These conjugates have been synthetized by tethering neomycin and guanidinoneomycin to PAMAM dendrimers of generations 2 and 4 through isothiocyanate‐amine click chemistry. The mechanism of entry depends on the presence of heparan sulfate proteoglycans on the cell surface, as no uptake has been observed in mutant cells lacking heparan sulfate. Stefano Pirola is acknowledged for the graphic design of the cover.

Inside Back Cover: Dendrimeric Guanidinoneomycin for Cellular Delivery of Bio-macromolecules (ChemBioChem 1/2017) / A. Sganappa, E. Wexselblatt, M.C. Bellucci, J.D. Esko, G. Tedeschi, Y. Tor, A. Volonterio. - In: CHEMBIOCHEM. - ISSN 1439-4227. - 18:1(2017 Jan 03), pp. 150-150. [10.1002/cbic.201600662]

Inside Back Cover: Dendrimeric Guanidinoneomycin for Cellular Delivery of Bio-macromolecules (ChemBioChem 1/2017)

M.C. Bellucci;G. Tedeschi;
2017

Abstract

The inside back cover picture shows the ability of dendrimeric amino‐ and, in a much more efficient way, guanidinoneomycin‐PAMAM vehicles to promote the cellular uptake of high‐molecular‐weight biologicals, such as enzymes or proteins. These conjugates have been synthetized by tethering neomycin and guanidinoneomycin to PAMAM dendrimers of generations 2 and 4 through isothiocyanate‐amine click chemistry. The mechanism of entry depends on the presence of heparan sulfate proteoglycans on the cell surface, as no uptake has been observed in mutant cells lacking heparan sulfate. Stefano Pirola is acknowledged for the graphic design of the cover.
Settore CHIM/06 - Chimica Organica
3-gen-2017
16-dic-2016
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/617795
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