Depression is a severe and life-threatening psychiatric illness whose pathogenesis is still essentially unknown. Proteomic analysis of synaptic terminals (synaptoproteomics) in animal models of depression is a powerful approach to gain insight into the molecular mechanisms underlying vulnerability to mood disorders and the long-term action of drug treatments. Here, we employed two different animal models of depression, the Learned Helplessness rats (a classical behavioral model of depression) and a new model of depression with gene - environment interaction (Flinders Sensitive Line rats subjected to early life stress). Both animal models were treated with the antidepressant escitalopram. Analysis of their synaptoproteomic profile revealed a number of protein spots differently regulated by basic vulnerability and/or early life stress. Using this approach, we obtained information regarding biomarkers that may represent predictors of pathology or response/resistance to drug treatment, as well as potential targets for novel pharmacological and therapeutic strategies.

Synaptoproteomics of existing and new animal models of depression / A. MALLEI, R. GIAMBELLI, A. EL KHOURY, S.H.M. GRUBER, L. MUSAZZI, V.S. BARBIERO, D. TARDITO, B. VOLLMAYR, P. GASS, A.A. MATHE, G. RACAGNI, M. POPOLI - In: Biomarkers for Psychiatric Disorders / [a cura di] C.W. Turck. - New York : Springer, 2009. - ISBN 9780387792507. - pp. 185-202 [10.1007/978-0-387-79251-4_8]

Synaptoproteomics of existing and new animal models of depression

A. Mallei
Primo
;
L. Musazzi;V.S. Barbiero;D. Tardito;G. Racagni
Penultimo
;
M. Popoli
Ultimo
2009

Abstract

Depression is a severe and life-threatening psychiatric illness whose pathogenesis is still essentially unknown. Proteomic analysis of synaptic terminals (synaptoproteomics) in animal models of depression is a powerful approach to gain insight into the molecular mechanisms underlying vulnerability to mood disorders and the long-term action of drug treatments. Here, we employed two different animal models of depression, the Learned Helplessness rats (a classical behavioral model of depression) and a new model of depression with gene - environment interaction (Flinders Sensitive Line rats subjected to early life stress). Both animal models were treated with the antidepressant escitalopram. Analysis of their synaptoproteomic profile revealed a number of protein spots differently regulated by basic vulnerability and/or early life stress. Using this approach, we obtained information regarding biomarkers that may represent predictors of pathology or response/resistance to drug treatment, as well as potential targets for novel pharmacological and therapeutic strategies.
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/61777
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