Post-transcriptional modifications are essential mechanisms for mRNA biogenesis and function in eukaryotic cells. Beyond well-characterized events such as splicing, capping, and polyadenylation, there are several others, as RNA editing mechanisms and regulation of transcription mediated by miRNAs that are taking increasing attention in the last years. RNA editing through A-to-I deamination increases transcriptomic complexity, generating different proteins with amino acid substitution from the same transcript. On the other hand, miRNAs can regulate gene expression modulating target mRNA decay and translation. Interestingly, recent studies highlight the possibility that miRNAs might undergo editing themselves. This mainly translates in the degradation or uncorrected maturation of miRNAs but also in the recognition of different targets. The presence of edited and unedited forms of the same miRNA may have important biological implications in both health and disease. Here we review ongoing investigations on miRNA RNA editing with the aim to shed light on the growing importance of this mechanism in adding complexity to post-transcriptional regulation of gene expression.

miRNA Editing: New Insights into the Fast Control of Gene Expression in Health and Disease / J. Mingardi, L. Musazzi, G. De Petro, A. Barbon. - In: MOLECULAR NEUROBIOLOGY. - ISSN 0893-7648. - 55:10(2018 Oct), pp. 7717-7727. [10.1007/s12035-018-0951-x]

miRNA Editing: New Insights into the Fast Control of Gene Expression in Health and Disease

L. Musazzi
Secondo
;
2018-10

Abstract

Post-transcriptional modifications are essential mechanisms for mRNA biogenesis and function in eukaryotic cells. Beyond well-characterized events such as splicing, capping, and polyadenylation, there are several others, as RNA editing mechanisms and regulation of transcription mediated by miRNAs that are taking increasing attention in the last years. RNA editing through A-to-I deamination increases transcriptomic complexity, generating different proteins with amino acid substitution from the same transcript. On the other hand, miRNAs can regulate gene expression modulating target mRNA decay and translation. Interestingly, recent studies highlight the possibility that miRNAs might undergo editing themselves. This mainly translates in the degradation or uncorrected maturation of miRNAs but also in the recognition of different targets. The presence of edited and unedited forms of the same miRNA may have important biological implications in both health and disease. Here we review ongoing investigations on miRNA RNA editing with the aim to shed light on the growing importance of this mechanism in adding complexity to post-transcriptional regulation of gene expression.
ADAR1; ADAR2; miRNA; RNA editing; Animals; Disease; Embryonic Development; Humans; MicroRNAs; Neoplasms; Neuronal Plasticity; RNA Editing; Health; Neuroscience (miscellaneous); Neurology; Cellular and Molecular Neuroscience
Settore BIO/13 - Biologia Applicata
Settore BIO/14 - Farmacologia
microRNA regulation of synaptic BDNF in the effects of ketamine on dendritic arborization and depressive-like behaviour
12-lug-2018
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/617442
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