1. Monotherapy with mitotane is recommended in patients after incomplete surgical resection or in patients not fit for surgery or chemotherapy 1 ⊕⊕OO. 2. Monotherapy with mitotane may be recommended in advanced ACC with involvement of few organs and low-grade mitotic index, particularly when RFS after removal of the primary tumor has been longer than 12 months 1 ⊕OOOO. 3. The chemotherapeutic regimen EDP in combination with mitotane is recommended in most patients with advanced or metastatic ACC 1 ⊕⊕⊕⊕. 4. There are insufficient data to recommend a particular targeted therapy in patients with advanced ACC beyond ongoing clinical trials.
Management of adrenocortical carcinoma : a consensus statement of the Italian Society of Endocrinology (SIE) / A. Stigliano, I. Chiodini, R. Giordano, A. Faggiano, L. Canu, S. Della Casa, P. Loli, M. Luconi, F. Mantero, M. Terzolo. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - 39:1(2016), pp. 103-121. [10.1007/s40618-015-0349-9]
Management of adrenocortical carcinoma : a consensus statement of the Italian Society of Endocrinology (SIE)
I. Chiodini;R. Giordano;
2016
Abstract
1. Monotherapy with mitotane is recommended in patients after incomplete surgical resection or in patients not fit for surgery or chemotherapy 1 ⊕⊕OO. 2. Monotherapy with mitotane may be recommended in advanced ACC with involvement of few organs and low-grade mitotic index, particularly when RFS after removal of the primary tumor has been longer than 12 months 1 ⊕OOOO. 3. The chemotherapeutic regimen EDP in combination with mitotane is recommended in most patients with advanced or metastatic ACC 1 ⊕⊕⊕⊕. 4. There are insufficient data to recommend a particular targeted therapy in patients with advanced ACC beyond ongoing clinical trials.
| File | Dimensione | Formato | |
|---|---|---|---|
|
86 - Management of ACC, A consensus statement of SIE - JENI 2016.pdf
accesso riservato
Tipologia:
Publisher's version/PDF
Dimensione
617.69 kB
Formato
Adobe PDF
|
617.69 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
