As main drivers of leukocyte recruitment during inflammatory reactions, chemokines act as mediatrs of alarmins in priming host defense responses after tissue exposure to toxic or infectious agents, immunomediated damage, and in inflammation-driven tumors. Chemokines can therefore be considered alarm signals generated by tissues in a broad number of conditions, and mechanisms controlling chemokines biological activities are therefore key to regulate tissue reactions induced by alarmins. By transporting, presenting or scavenging different sets of chemokines, atypical chemokine receptors represent an emerign subfamily of chemokine receptors which operates in tissues as chemokine gatekeepers in order to establish and shape their gradients and coordinate leukocyte recruitment.

Chemokines sound the alarmin : the role of atypical chemokine in inflammation and cancer / E.M. Borroni, B. Savino, R. Bonecchi, M. Locati. - In: SEMINARS IN IMMUNOLOGY. - ISSN 1044-5323. - 38(2018 Aug 01), pp. 63-71. [10.1016/j.smim.2018.10.005]

Chemokines sound the alarmin : the role of atypical chemokine in inflammation and cancer

Borroni, Elena Monica;Savino, Benedetta;Bonecchi, Raffaella;Locati, Massimo
2018-08-01

Abstract

As main drivers of leukocyte recruitment during inflammatory reactions, chemokines act as mediatrs of alarmins in priming host defense responses after tissue exposure to toxic or infectious agents, immunomediated damage, and in inflammation-driven tumors. Chemokines can therefore be considered alarm signals generated by tissues in a broad number of conditions, and mechanisms controlling chemokines biological activities are therefore key to regulate tissue reactions induced by alarmins. By transporting, presenting or scavenging different sets of chemokines, atypical chemokine receptors represent an emerign subfamily of chemokine receptors which operates in tissues as chemokine gatekeepers in order to establish and shape their gradients and coordinate leukocyte recruitment.
Atypical chemokine receptors; Cancer related inflammation; Chemokines; Scavenger receptors; Immunology and Allergy; Immunology
Settore MED/04 - Patologia Generale
SEMINARS IN IMMUNOLOGY
http://hdl.handle.net/2434/767064
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/614926
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