A collection of systematically substituted 3-cyclo-butylcarbamoyl hydantoins was synthesized by a regioselective multicomponent domino process followed by easy coupling reactions. Calculations, NMR studies and X-ray analysis show that these scaffolds are able to project their side chains similar to common secondary structures, such as the α-helix and β-turn, with favourable enthalpic and entropic profiles.
Design, synthesis, and conformational analysis of 3-cyclo-butylcarbamoyl hydantoins as novel hydrogen bond driven universal peptidomimetics / M.C. Bellucci, M. Frigerio, C. Castellano, F. Meneghetti, A. Sacchetti, A. Volonterio. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - 16:4(2018 Jan 24), pp. 521-525.
Titolo: | Design, synthesis, and conformational analysis of 3-cyclo-butylcarbamoyl hydantoins as novel hydrogen bond driven universal peptidomimetics | |
Autori: | ||
Settore Scientifico Disciplinare: | Settore CHIM/08 - Chimica Farmaceutica Settore CHIM/03 - Chimica Generale e Inorganica Settore CHIM/06 - Chimica Organica | |
Data di pubblicazione: | 24-gen-2018 | |
Rivista: | ||
Tipologia: | Article (author) | |
Data ahead of print / Data di stampa: | 6-dic-2017 | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1039/c7ob02680c | |
Appare nelle tipologie: | 01 - Articolo su periodico |
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