International validation of the revised European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module, the EORTC QLQ-HN43: Phase IV

Singer, S.; Amdal, C.D.; Hammerlid, E.; Tomaszewska, I.M.; Castro Silva, J.; Mehanna, H.; Santos, M.; Inhestern, J.; Brannan, C.; Yarom, N.; Fullerton, A.; Pinto, M.; Arraras, J.I.; Kiyota, N.; Bonomo, P.; Sherman, A.C.; Baumann, I.; Galalae, R.; Fernandez Gonzalez, L.; Nicolatou-Galitis, O.; Abdel-Hafeez, Z.; Raber-Durlacher, J.; Schmalz, C.; Zotti, P.; Boehm, A.; Hofmeister, D.; Krejovic Trivic, S.; Loo, S.; Chie, W.; Bjordal, K.; Brokstad Herlofson, B.; Grégoire, V.; Licitra, L.

doi:10.1002/hed.25609

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Background: We validated the new European Organisation for Research and Treatment of Cancer Quality of Life Head and Neck Module (EORTC QLQ-HN43). Methods: We enrolled 812 patients with head and neck cancer from 18 countries. Group 1 completed the questionnaire before therapy, and 3 and 6 months later. In group 2 (survivors), we determined test–retest reliability using intraclass correlation coefficients (ICC). Internal consistency was assessed using Cronbach's Alpha, the scale structure with confirmatory factor analysis, and discriminant validity with known-group comparisons. Results: Cronbach's alpha was >0.70 in 10 of the 12 multi-item scales. All standardized factor loadings exceeded 0.40. The ICC was >0.70 in all but two scales. Differences in scale scores between known-groups were >10 points in 17 of the 19 scales. Sensitivity to change was found to be sufficient in 18 scales. Conclusions: Evidence supports the reliability and validity of the EORTC QLQ-HN43 as a measure of quality of life.

International validation of the revised European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module, the EORTC QLQ-HN43: Phase IV / S. Singer, C.D. Amdal, E. Hammerlid, I.M. Tomaszewska, J. Castro Silva, H. Mehanna, M. Santos, J. Inhestern, C. Brannan, N. Yarom, A. Fullerton, M. Pinto, J.I. Arraras, N. Kiyota, P. Bonomo, A.C. Sherman, I. Baumann, R. Galalae, L. Fernandez Gonzalez, O. Nicolatou-Galitis, Z. Abdel-Hafeez, J. Raber-Durlacher, C. Schmalz, P. Zotti, A. Boehm, D. Hofmeister, S. Krejovic Trivic, S. Loo, W. Chie, K. Bjordal, B. Brokstad Herlofson, V. Grégoire, L. Licitra. - In: HEAD & NECK. - ISSN 1043-3074. - (2019 Jan 12). [Epub ahead of print]

Titolo:	International validation of the revised European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module, the EORTC QLQ-HN43: Phase IV
Autori:	Singer, Susanne Amdal, Cecilie Delphin Hammerlid, Eva Tomaszewska, Iwona M Castro Silva, Joaquim Mehanna, Hisham Santos, Marcos Inhestern, Johanna Brannan, Christine Yarom, Noam Fullerton, Amy Pinto, Monica Arraras, Juan I Kiyota, Naomi Bonomo, Pierluigi Sherman, Allen C Baumann, Ingo Galalae, Razvan Fernandez Gonzalez, Loreto Nicolatou-Galitis, Ourania Abdel-Hafeez, Zeinab Raber-Durlacher, Judith Schmalz, Claudia Zotti, Paola Boehm, Andreas Hofmeister, Dirk Krejovic Trivic, Sanja Loo, Suat Chie, Wei-Chu Bjordal, Kristin Brokstad Herlofson, Bente Grégoire, Vincent LICITRA, LISA FRANCESCA LINDA mostra contributor esterni nascondi contributor esterni
Parole Chiave:	chemoradiation; head and neck cancer; multimodal therapies; quality of life; validation;
Settore Scientifico Disciplinare:	Settore MED/06 - Oncologia Medica
Data di pubblicazione:	12-gen-2019
Rivista:	HEAD & NECK
Tipologia:	Article (author)
Digital Object Identifier (DOI):	http://dx.doi.org/10.1002/hed.25609
Appare nelle tipologie:	01 - Articolo su periodico

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