Low-dose acetylsalicylic acid (ASA, 100 mg/die) is used in thromboprophylaxis. Enteric-coated formulation (EC-ASA) is commonly used for its lower risk of side effects. Some patients on EC-ASA do not respond appropriately and recent studies showed that poor responsiveness is more frequent with EC-ASA [1]. Aim of this study was to validate a method useful to study the pharmacokinetics (PK) of ASA in healthy subjects treated with two different aspirin formulations.
Pharmacokinetics and bioavailability of different acetylsalicylic acid formulations assessed by liquid chromatography-tandem mass spectrometry in healthy subjects / J. Rizzo, M. Dei Cas, F.M. Rubino, R.C. Paroni - In: XXII International Mass Spectrometry Conference : abstract book / [a cura di] G. Giorgi. - Prima edizione. - [s.l] : International Mass Spectrometry Foundation, 2018 Nov. - ISBN 9788890738852. - pp. 392-393 (( Intervento presentato al 22. convegno International Mass Spectrometry Conference tenutosi a Firenze nel 2018.
Pharmacokinetics and bioavailability of different acetylsalicylic acid formulations assessed by liquid chromatography-tandem mass spectrometry in healthy subjects
J. RizzoPrimo
Membro del Collaboration Group
;M. Dei CasSecondo
Membro del Collaboration Group
;F.M. RubinoPenultimo
Membro del Collaboration Group
;R.C. Paroni
Ultimo
Membro del Collaboration Group
2018
Abstract
Low-dose acetylsalicylic acid (ASA, 100 mg/die) is used in thromboprophylaxis. Enteric-coated formulation (EC-ASA) is commonly used for its lower risk of side effects. Some patients on EC-ASA do not respond appropriately and recent studies showed that poor responsiveness is more frequent with EC-ASA [1]. Aim of this study was to validate a method useful to study the pharmacokinetics (PK) of ASA in healthy subjects treated with two different aspirin formulations.
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