Myriocin (Myr) is a suicide inactivator of ceramide synthesis with a complex lipid multifunctional structure. Its biological activity is exerted at very low doses, and thus highly performing quantitative method are needed [1]. The pharmacological development of Myr to modulate ceramide levels also requires currently unavailable ADME information in healthy and pathological animal models.

Pharmacokinetic of myriocin in rabbit’s eyes / M. Dei Cas, F.M. Rubino, J. Rizzo, P. Signorelli, E. Strettoi, C. Platania, C. Bucolo, R. Pignatello, R. Ghidoni, R.C. Paroni - In: XXII International Mass Spectrometry Conference : abstract book / [a cura di] G. Giorgi. - Prima edizione. - Firenze : International Mass Spectrometry Foundation, 2018 Nov. - ISBN 9788890738852. - pp. 374-375 (( Intervento presentato al 22. convegno International mass spectrometry conference tenutosi a Firenze nel 2018.

Pharmacokinetic of myriocin in rabbit’s eyes

M. Dei Cas
Primo
Membro del Collaboration Group
;
F.M. Rubino
Secondo
Membro del Collaboration Group
;
J. Rizzo
Membro del Collaboration Group
;
P. Signorelli
Membro del Collaboration Group
;
C. Platania;R. Ghidoni
Penultimo
;
R.C. Paroni
Ultimo
2018-11

Abstract

Myriocin (Myr) is a suicide inactivator of ceramide synthesis with a complex lipid multifunctional structure. Its biological activity is exerted at very low doses, and thus highly performing quantitative method are needed [1]. The pharmacological development of Myr to modulate ceramide levels also requires currently unavailable ADME information in healthy and pathological animal models.
myriocin; pharmacokinetic; drug delivery; eye; qTrap
Settore BIO/10 - Biochimica
Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
Settore CHIM/01 - Chimica Analitica
International Mass Spectrometry Society
Società Chimica Italiana
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/611648
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