An intravenous infusion of 2,000 ml isotonic saline was performed in 8 normotensive, normoreninemic patients with progressive systemic sclerosis. None of them had clinical evidence of renal disease. Total and proximal fractional excretion of sodium was reduced when compared with that of 8 normal subjects. No correlation was found with para-aminohippurate (PAH) clearance values. Two years after this study was done, 4 patients developed arterial hypertension; interestingly, plasma renin activity remained within the normal range. Reduced sodium excretion is suggested as having a pathogenetic role in the hypertension of progressive systemic sclerosis.
Functional renal involvement in normotensive patients with progressive systemic sclerosis: impaired sodium excretion during isotonic saline infusion / A. D'Angelo, P. Messa, U. Fiocco, A. Fabris, P. Morachiello, G. Senesi, S. Todesco. - In: ARTHRITIS AND RHEUMATISM. - ISSN 0004-3591. - 24:1(1981 Jan), pp. 8-11.
Titolo: | Functional renal involvement in normotensive patients with progressive systemic sclerosis: impaired sodium excretion during isotonic saline infusion |
Autori: | |
Parole Chiave: | Adolescent; Adult; Aged; Female; Humans; Hypertension; Isotonic Solutions; Kidney; Male; Middle Aged; Renin; Scleroderma, Systemic; Sodium; Sodium Chloride |
Settore Scientifico Disciplinare: | Settore MED/14 - Nefrologia |
Data di pubblicazione: | gen-1981 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/art.1780240102 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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