The public availability of numerous microbial genomes is enabling the analysis of bacterial biology in great detail and with an unprecedented, organism-wide and taxon-wide, broad scope. Streptococcus pneumoniae is one of the most important bacterial pathogens throughout the world. We present here sequences and functional annotations for 2.1-Mbp of pneumococcal DNA, covering more than 90% of the total estimated size of the genome. The sequenced strain is a clinical isolate resistant to macrolides and tetracycline. It carries a type 19F capsular locus, but multilocus sequence typing for several conserved genetic loci suggests that the strain sequenced belongs to a pneumococcal lineage that most often expresses a serotype 15 capsular polysaccharide. A total of 2,046 putative open reading frames (ORFs) longer than 100 amino acids were identified (average of 1,009 bp per ORF), including all described two-component systems and aminoacyl tRNA synthetases. Comparisons to other complete, or nearly complete, bacterial genomes were made and are presented in a graphical form for all the predicted proteins.
Annotated draft genomic sequence from a Streptococcus pneumoniae type 19F clinical isolate / J. Dopazo, A. Mendoza, J. Herrero, F. Caldara, Y. Humbert, L. Friedli, M. Guerrier, E. Grand-Schenk, C. Gandin, M. de Francesco, A. Polissi, G. Buell, G. Feger, E. García, M. Peitsch, J.F. García-Bustos. - In: MICROBIAL DRUG RESISTANCE. - ISSN 1076-6294. - 7:2(2001), pp. 99-125.
|Titolo:||Annotated draft genomic sequence from a Streptococcus pneumoniae type 19F clinical isolate|
|Parole Chiave:||Conjugative transposon TN5252; nucleotide-sequence; gene; identification; transformation; resistance; tool|
|Settore Scientifico Disciplinare:||Settore BIO/19 - Microbiologia Generale|
|Data di pubblicazione:||2001|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1089/10766290152044995|
|Appare nelle tipologie:||01 - Articolo su periodico|