Histological characteristics and clinical behaviour define lung neuroendocrine tumors (NETs), which are classified into four groups: typical (TC) and atypical carcinoids (AC), large-cell neuroendocrine carcinomas (LCNCs) and small-cell lung cancers (SCLCs). Historically, outcome and treatment of these rare neoplasms have been based on small, usually mono-institutional clinical series. Furthermore, their rarity makes quite impossible to design randomised clinical trial to compare different treatments especially in unusual clinical presentations. In 2012, the European Society of Thoracic Surgeons (ESTS) launched a new working-group, specifically dedicated to lung NETs, with the aim to develop modern knowledge on biology and behaviour of these tumors, and to disseminate it within the scientific community. A dedicated retrospective database was at first developed and sent to all the ESTS centres interested to this project. More than 2,000 operated NETs cases have been rapidly collected, and they represented the clinical substrate of several published scientific studies. The retrospective data collection intrinsic limitations in term of patients' selection and treatment, along with the problem of possible missing data, were the reasons why the ESTS NETs working-group decided in 2015 to design and promote a new prospective database, employing the official ESTS platform. The aim of this review paper is to report the ESTS Lung NETs working-group history and to explain the architecture and use of the lung NETs databases.
The European Society of Thoracic Surgeons (ESTS) lung neuroendocrine tumors (NETs) database / P.L. Filosso, P.E. Falcoz, P. Solidoro, D. Pellicano, S. Passani, F. Guerrera, E. Ruffini, C. Casadio, O. Rena, P.M. Rena, A. Alvarez, D. Sagan, P. Carbognani, L. Ampollini, N. Asadi, F. Stella, M. Nosotti, L. Santambrogio, P.A. Thomas, L. Gust, C. Pompili, A. Brunelli, S. Margaritora, M. Chiappetta, C. Roesel, E.A.R. G. Maurizi. - In: JOURNAL OF THORACIC DISEASE. - ISSN 2072-1439. - 10:Suppl 29(2018 Oct 01), pp. S3528-S3532.
|Titolo:||The European Society of Thoracic Surgeons (ESTS) lung neuroendocrine tumors (NETs) database|
|Parole Chiave:||Lung; neuroendocrine tumors (NETs); outcome; prospective database; retrospective database|
|Settore Scientifico Disciplinare:||Settore MED/21 - Chirurgia Toracica|
|Data di pubblicazione:||1-ott-2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.21037/jtd.2018.04.104|
|Appare nelle tipologie:||01 - Articolo su periodico|
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