Blood, serum and plasma represent accessible sources of data about physiological and pathologic status. In arrhythmogenic cardiomyopathy (ACM), circulating nucleated cells are routinely used for detection of germinal genetic mutations. In addition, different biomarkers have been proposed for diagnostic purposes and for monitoring disease progression, including inflammatory cytokines, markers of myocardial dysfunction and damage, and microRNAs. This review summarizes the current information that can be retrieved from the blood of ACM patients and considers the future prospects. Improvements in current knowledge of circulating factors may provide noninvasive means to simplify and improve the diagnosis, prognosis prediction, and management of ACM patients.
Arrhythmogenic cardiomyopathy: what blood can reveal? / I. Stadiotti, G. Pompilio, A.S. Maione, C.A. Pilato, Y. D'Alessandra, E. Sommariva. - In: HEART RHYTHM. - ISSN 1547-5271. - 16:3(2019), pp. 470-477.
Titolo: | Arrhythmogenic cardiomyopathy: what blood can reveal? |
Autori: | STADIOTTI, ILARIA (Primo) POMPILIO, GIULIO (Secondo) D'ALESSANDRA, YURI (Penultimo) |
Parole Chiave: | Arrhythmogenic right ventricular cardiomyopathy; Biomarkers; Blood; Genetics; Heart failure; Inflammation; Plasma; Serum; microRNA |
Settore Scientifico Disciplinare: | Settore BIO/11 - Biologia Molecolare |
Data di pubblicazione: | 2019 |
Rivista: | |
Tipologia: | Article (author) |
Data ahead of print / Data di stampa: | 26-set-2018 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.hrthm.2018.09.023 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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