Doxorubicin (DOX) is a chemotherapeutic drug limited in its usefulness by an adverse side effect, cardiotoxicity. The mechanisms leading to this detrimental occurrence are not completely clear, and lately many authors focused their attention on the possible role of microRNAs (miRNAs), small regulators of cardiovascular functions, in this phenomenon. Notably, these molecules recently emerged also as potential circulating biomarkers of several cardiac diseases. Thus, the aim of this study was the simultaneous investigation of circulating and cardiac tissue miRNAs expression upon DOX treatment in vivo.
Plasmatic and chamber-specific modulation of cardiac microRNAs in an acute model of DOX-induced cardiotoxicity / S. Gioffré, V. Ricci, C. Vavassori, C. Ruggeri, M. Chiesa, I. Alfieri, S. Zorzan, M. Buzzetti, G. Milano, A. Scopece, L. Castiglioni, L. Sironi, G. Pompilio, G.I. Colombo, Y. D'Alessandra. - In: BIOMÉDECINE & PHARMACOTHÉRAPIE. - ISSN 0753-3322. - 110(2019 Feb), pp. 1-8.
|Titolo:||Plasmatic and chamber-specific modulation of cardiac microRNAs in an acute model of DOX-induced cardiotoxicity|
D'ALESSANDRA, YURI (Corresponding)
|Parole Chiave:||Biomarkers; Cardiotoxicity; Circulating microRNA; Doxorubicin; Heart chambers; microRNAs|
|Settore Scientifico Disciplinare:||Settore BIO/11 - Biologia Molecolare|
|Data di pubblicazione:||feb-2019|
|Data ahead of print / Data di stampa:||16-nov-2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.biopha.2018.11.042|
|Appare nelle tipologie:||01 - Articolo su periodico|