Doxorubicin (DOX) is a chemotherapeutic drug limited in its usefulness by an adverse side effect, cardiotoxicity. The mechanisms leading to this detrimental occurrence are not completely clear, and lately many authors focused their attention on the possible role of microRNAs (miRNAs), small regulators of cardiovascular functions, in this phenomenon. Notably, these molecules recently emerged also as potential circulating biomarkers of several cardiac diseases. Thus, the aim of this study was the simultaneous investigation of circulating and cardiac tissue miRNAs expression upon DOX treatment in vivo.

Plasmatic and chamber-specific modulation of cardiac microRNAs in an acute model of DOX-induced cardiotoxicity / S. Gioffré, V. Ricci, C. Vavassori, C. Ruggeri, M. Chiesa, I. Alfieri, S. Zorzan, M. Buzzetti, G. Milano, A. Scopece, L. Castiglioni, L. Sironi, G. Pompilio, G.I. Colombo, Y. D'Alessandra. - In: BIOMÉDECINE & PHARMACOTHÉRAPIE. - ISSN 0753-3322. - 110(2019 Feb), pp. 1-8.

Plasmatic and chamber-specific modulation of cardiac microRNAs in an acute model of DOX-induced cardiotoxicity

C. Vavassori;L. Castiglioni;L. Sironi;G. Pompilio;Y. D'Alessandra
2019-02

Abstract

Doxorubicin (DOX) is a chemotherapeutic drug limited in its usefulness by an adverse side effect, cardiotoxicity. The mechanisms leading to this detrimental occurrence are not completely clear, and lately many authors focused their attention on the possible role of microRNAs (miRNAs), small regulators of cardiovascular functions, in this phenomenon. Notably, these molecules recently emerged also as potential circulating biomarkers of several cardiac diseases. Thus, the aim of this study was the simultaneous investigation of circulating and cardiac tissue miRNAs expression upon DOX treatment in vivo.
Biomarkers; Cardiotoxicity; Circulating microRNA; Doxorubicin; Heart chambers; microRNAs
Settore BIO/11 - Biologia Molecolare
16-nov-2018
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/610434
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