In a cohort of elderly men in the Boston area, we sought to determine whether: i) recent exposure to black carbon (BC), a marker of traffic particles, was associated with decreased genomic DNA methylation content estimated in LINE-1 and Alu repetitive elements; ii) decreased genomic DNA methylation was associated with cardiovascular factors, including arterial blood pressure, serum levels of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), diagnosis of Coronary Heart Disease (CHD) and stroke, and statin use.
Coordinatore scientifico di Normative Aging Study(2006 Jan).
Coordinatore scientifico di Normative Aging Study
2006
Abstract
In a cohort of elderly men in the Boston area, we sought to determine whether: i) recent exposure to black carbon (BC), a marker of traffic particles, was associated with decreased genomic DNA methylation content estimated in LINE-1 and Alu repetitive elements; ii) decreased genomic DNA methylation was associated with cardiovascular factors, including arterial blood pressure, serum levels of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), diagnosis of Coronary Heart Disease (CHD) and stroke, and statin use.
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