Many hormone receptor-positive tumors show primary or acquired resistance, possibly because of a crosstalk with other growth factor-related transduction pathways (mainly epidermal growth factor receptor family related). The LETLOB study is a European multicenter, placebo-controlled, randomized phase II trial in postmenopausal patients with hormone-sensitive, HER2-negative, stage II-IIIA (T > 2 cm, N0-1, M0) breast cancer, in which letrozole or the combination of letrozole plus lapatinib will be administered for 6 months before surgery. Clinical endpoints (primary [ultrasonographic objective response], secondary [rate of pathologic complete response and of conservative surgery, safety, and time to treatment failure], and biologic [inhibition of intermediate and final biomarkers of the proliferative and apoptosis pathways and gene profile correlation with response]) will be evaluated.
|Titolo:||Letrozole versus letrozole plus Lapatinib (GW572016) in hormone-sensitive, HER2-negative operable breast cancer : a double-blind, randomized, phase II study with biomarker evaluation (EGF109077-LAP107692/LETLOB)|
|Parole Chiave:||Mitogen-activated protein kinase; Multigated acquisition scan; Tyrosine kinase inhibitor|
|Data di pubblicazione:||feb-2008|
|Digital Object Identifier (DOI):||10.3816/CBC.2008.n.010|
|Appare nelle tipologie:||01 - Articolo su periodico|