Spreading of neoplastic cells from colon cancer to regional lymph nodes (LN) is often associated with distant recurrence. However, a number of clinical trials have shown that lymphadenectomy is not increasing Colon Cancer (CC) patient’s survival. This phenomenon is probably due to a metastatic dissemination that occurs via the systemic blood circulation, rather than the lymphatic vessels. How such dissemination is achieved is unknown. We hypothesized that the disruption of the vasculature in colon tumors can be linked to cancer cells dissemination. We identified a new marker of deranged vasculature which is expressed in primary tumors of CC patients that have developed metachronous distant metastases, independently from the presence of metastases in regional LN. Moreover, we studied vasculature disruption in a mouse model that develops spontaneous tumors mainly in the colon. These mice showed dismantled vasculature at tumor level and they concomitantly exhibited the formation of a pre-metastatic niche at distant sites which favored the recruitment of metastatic cells. Vascular impairment can shed light on the process of colon metastases and this new marker can be used as a prognostic marker for distant recurrence.

ROLE OF THE GUT VASCULAR BARRIER IN METASTATIC COLON CANCER / A. Bertocchi ; internal supervisor: U. Cavallaro ; supervisor: M. Rescigno. DIPARTIMENTO DI SCIENZE DELLA SALUTE, 2019 Jan 28. 30. ciclo, Anno Accademico 2018. [10.13130/bertocchi-alice_phd2019-01-28].

ROLE OF THE GUT VASCULAR BARRIER IN METASTATIC COLON CANCER

A. Bertocchi
2019

Abstract

Spreading of neoplastic cells from colon cancer to regional lymph nodes (LN) is often associated with distant recurrence. However, a number of clinical trials have shown that lymphadenectomy is not increasing Colon Cancer (CC) patient’s survival. This phenomenon is probably due to a metastatic dissemination that occurs via the systemic blood circulation, rather than the lymphatic vessels. How such dissemination is achieved is unknown. We hypothesized that the disruption of the vasculature in colon tumors can be linked to cancer cells dissemination. We identified a new marker of deranged vasculature which is expressed in primary tumors of CC patients that have developed metachronous distant metastases, independently from the presence of metastases in regional LN. Moreover, we studied vasculature disruption in a mouse model that develops spontaneous tumors mainly in the colon. These mice showed dismantled vasculature at tumor level and they concomitantly exhibited the formation of a pre-metastatic niche at distant sites which favored the recruitment of metastatic cells. Vascular impairment can shed light on the process of colon metastases and this new marker can be used as a prognostic marker for distant recurrence.
28-gen-2019
Settore MED/04 - Patologia Generale
Metastatic Colon Cancer; Tumor Vessels; Premetastatic niche
MINUCCI, SAVERIO
RESCIGNO, MARIA
Doctoral Thesis
ROLE OF THE GUT VASCULAR BARRIER IN METASTATIC COLON CANCER / A. Bertocchi ; internal supervisor: U. Cavallaro ; supervisor: M. Rescigno. DIPARTIMENTO DI SCIENZE DELLA SALUTE, 2019 Jan 28. 30. ciclo, Anno Accademico 2018. [10.13130/bertocchi-alice_phd2019-01-28].
File in questo prodotto:
File Dimensione Formato  
phd_unimi_R11133.pdf

Open Access dal 12/12/2020

Descrizione: Tesi Dottorato
Tipologia: Tesi di dottorato completa
Dimensione 37.29 MB
Formato Adobe PDF
37.29 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/608839
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact