Despite the significant recent achievements in the diagnosis and treatment of colorectal cancer (CRC), the prognosis of these patients has currently plateaued. During the past few years, the opportunity to consider multiple treatment modalities (including surgery and other locoregional treatments, systemic therapy, and targeted therapy) led to the research of novel prognostic and predictive biomarkers in CRC liver metastases (CRCLM) patients. In this review, we seek to describe the current state of knowledge of CRCLM biomarkers and to outline impending clinical perspectives, in particular focusing on the cutting-edge tools available for their characterization.
Molecular and immunohistochemical markers with prognostic and predictive significance in liver metastases from colorectal carcinoma / G. Lopez, F. Boggio, S. Ferrero, N. Fusco, A. Del Gobbo. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 19:10(2018 Oct), pp. 3014.1-3014.18. [10.3390/ijms19103014]
Molecular and immunohistochemical markers with prognostic and predictive significance in liver metastases from colorectal carcinoma
G. LopezPrimo
;S. Ferrero;N. Fusco
;
2018
Abstract
Despite the significant recent achievements in the diagnosis and treatment of colorectal cancer (CRC), the prognosis of these patients has currently plateaued. During the past few years, the opportunity to consider multiple treatment modalities (including surgery and other locoregional treatments, systemic therapy, and targeted therapy) led to the research of novel prognostic and predictive biomarkers in CRC liver metastases (CRCLM) patients. In this review, we seek to describe the current state of knowledge of CRCLM biomarkers and to outline impending clinical perspectives, in particular focusing on the cutting-edge tools available for their characterization.File | Dimensione | Formato | |
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[2018] ijms-19-03014.pdf
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