Yeast-like filamentous fungi, collected in Italy from 1985 to 2018, were submitted to molecular identification and antifungal susceptibility testings. Clinical isolates were identified as Magnusiomyces capitatus (28), M. clavatus (18), and Geotrichum candidum (2). M. clavatus was prevalent among blood isolates (18/24), M. capitatus among isolates from other biological materials. The intrinsic echinocandin resistance was confirmed. Both species had low minimum inhibitory concentrations (MICs) of itraconazole, posaconazole, and voriconazole, while M. clavatus had lower MIC of flucytosine and higher MIC of isavuconazole than M. capitatus. The intrinsic resistance of these species to echinocandins could be the reason of the recent increase of M. clavatus bloodstream infections.

Yeast-like filamentous fungi: Molecular identification and in vitro susceptibility study / M.C. Esposto, A. Prigitano, G. Lo Cascio, C. Ossi, A. Grancini, C. Cavanna, F. Lallitto, M. Tejada, R. Bandettini, A. Mularoni, A.M. Tortorano. - In: MEDICAL MYCOLOGY. - ISSN 1369-3786. - 57:7(2019 Oct), pp. 909-913. [10.1093/mmy/myy133]

Yeast-like filamentous fungi: Molecular identification and in vitro susceptibility study

M.C. Esposto
Primo
;
A. Prigitano
Secondo
;
F. Lallitto;A.M. Tortorano
Ultimo
2019-10

Abstract

Yeast-like filamentous fungi, collected in Italy from 1985 to 2018, were submitted to molecular identification and antifungal susceptibility testings. Clinical isolates were identified as Magnusiomyces capitatus (28), M. clavatus (18), and Geotrichum candidum (2). M. clavatus was prevalent among blood isolates (18/24), M. capitatus among isolates from other biological materials. The intrinsic echinocandin resistance was confirmed. Both species had low minimum inhibitory concentrations (MICs) of itraconazole, posaconazole, and voriconazole, while M. clavatus had lower MIC of flucytosine and higher MIC of isavuconazole than M. capitatus. The intrinsic resistance of these species to echinocandins could be the reason of the recent increase of M. clavatus bloodstream infections.
Geotrichum; Magnusiomyces; Saprochaete; fungemia; yeast-like filamentous fungi;
Settore MED/42 - Igiene Generale e Applicata
6-dic-2018
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/607317
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