Neural tube defects (NTDs) are the second most common congenital malformations in humans affecting the development of the central nervous system. Although NTD pathogenesis has not yet been fully elucidated, many risk factors, both genetic and environmental, have been extensively reported. Classically divided in two main sub-groups (open and closed defects) NTDs present extremely variable prognosis mainly depending on the site of the lesion. Herein, we review the literature on the histological and pathological features, epidemiology, prenatal diagnosis, and prognosis, based on the type of defect, with the aim of providing important information based on NTDs classification for clinicians and scientists.

Overview on neural tube defects : from development to physical characteristics / L. Avagliano, V. Massa, T.M. George, S. Qureshy, G.P. Bulfamante, R.H. Finnell. - In: BIRTH DEFECTS RESEARCH. PART A, CLINICAL AND MOLECULAR TERATOLOGY. - ISSN 1542-0752. - (2018 Nov 12). [Epub ahead of print] [10.1002/bdr2.1380]

Overview on neural tube defects : from development to physical characteristics

L. Avagliano;V. Massa
;
G.P. Bulfamante;
2018-11-12

Abstract

Neural tube defects (NTDs) are the second most common congenital malformations in humans affecting the development of the central nervous system. Although NTD pathogenesis has not yet been fully elucidated, many risk factors, both genetic and environmental, have been extensively reported. Classically divided in two main sub-groups (open and closed defects) NTDs present extremely variable prognosis mainly depending on the site of the lesion. Herein, we review the literature on the histological and pathological features, epidemiology, prenatal diagnosis, and prognosis, based on the type of defect, with the aim of providing important information based on NTDs classification for clinicians and scientists.
anencephaly; neural tube defects; spina bifida; Pediatrics, Perinatology and Child Health; Embryology; Toxicology; Developmental Biology; Health, Toxicology and Mutagenesis
Settore BIO/13 - Biologia Applicata
Settore MED/40 - Ginecologia e Ostetricia
Settore MED/08 - Anatomia Patologica
12-nov-2018
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/607310
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