In the last two decades, much attention was devoted to novel multifunctional nanostructures based on magnetic nanoparticles (MNPs) useful as agents for Magnetic Resonance Imaging, Optical Imaging and Magnetic Fluid Hyperthermia, carriers for drugs and molecular targeting vectors. Most of the magnetic nanoparticles systems reported in literature by a lot of research groups, have been shown to be useful as MRI contrast agents and magnetic fluid hyperthermia (MFH) mediators, displaying high nuclear relaxivity and Specific Absorption Rate (SAR). For these compounds, the possibility to collect images of the regions where the MNPs are delivered through MRI and eventually Optical Imaging (if functionalized with a luminescent molecule), is joint to their use under radio-frequency fields, with frequency of the order of 100 KHz, which causes a local release of heat directed to tumour cells (the MFH effect), possibly inducing their death. By such materials, theranostic agents can be obtained. On the other hand, in the field of drug delivery and molecular targeting, few examples of reproducible experiments using superparamagnetic nanoparticles are actually present in literature. Thus, the applications of MNPs to nanomedicine is currently of growing interest in the world. The main objectives of my research group in the last decade was to contribute to the knowledge of physical mechanisms at the basis of MNPs uses in biomedicine (especially MRI) and to propose some novel systems in strict collaboration with different research groups of chemists and biologists. I will present different novel systems able to contrast MRI images, act as good Magnetic Fluid Hyperthermia agent or as multifunctional (magnetofluorescent) agent and carry antitumoral drugs like e.g Paclitaxel or targeting functionalizations like PNA (Peptide Nucleic Acids). Other examples of biomedical applications of MNPs magnetism will be also illustrated.

Magnetic nanoparticles: the effect of chemico-physical parameters on their fundamental and biomedical applicative properties / P. Arosio. - In: JOURNAL OF MATERIAL SCIENCES & ENGINEERING. - ISSN 2169-0022. - 7:(2018), pp. 64-64. ((Intervento presentato al 6. convegno International Conference and Exhibition on Materials Science and Chemistry tenutosi a Roma nel 2018.

Magnetic nanoparticles: the effect of chemico-physical parameters on their fundamental and biomedical applicative properties

P. Arosio
Primo
2018

Abstract

In the last two decades, much attention was devoted to novel multifunctional nanostructures based on magnetic nanoparticles (MNPs) useful as agents for Magnetic Resonance Imaging, Optical Imaging and Magnetic Fluid Hyperthermia, carriers for drugs and molecular targeting vectors. Most of the magnetic nanoparticles systems reported in literature by a lot of research groups, have been shown to be useful as MRI contrast agents and magnetic fluid hyperthermia (MFH) mediators, displaying high nuclear relaxivity and Specific Absorption Rate (SAR). For these compounds, the possibility to collect images of the regions where the MNPs are delivered through MRI and eventually Optical Imaging (if functionalized with a luminescent molecule), is joint to their use under radio-frequency fields, with frequency of the order of 100 KHz, which causes a local release of heat directed to tumour cells (the MFH effect), possibly inducing their death. By such materials, theranostic agents can be obtained. On the other hand, in the field of drug delivery and molecular targeting, few examples of reproducible experiments using superparamagnetic nanoparticles are actually present in literature. Thus, the applications of MNPs to nanomedicine is currently of growing interest in the world. The main objectives of my research group in the last decade was to contribute to the knowledge of physical mechanisms at the basis of MNPs uses in biomedicine (especially MRI) and to propose some novel systems in strict collaboration with different research groups of chemists and biologists. I will present different novel systems able to contrast MRI images, act as good Magnetic Fluid Hyperthermia agent or as multifunctional (magnetofluorescent) agent and carry antitumoral drugs like e.g Paclitaxel or targeting functionalizations like PNA (Peptide Nucleic Acids). Other examples of biomedical applications of MNPs magnetism will be also illustrated.
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
https://materialschemistry.chemistryconferences.org/2018/scientific-program.php?day=2&sid=4472&date=2018-05-18
Article (author)
File in questo prodotto:
File Dimensione Formato  
Proceedings Roma 2018.pdf

accesso aperto

Tipologia: Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione 262.05 kB
Formato Adobe PDF
262.05 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/606446
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact