The gene encoding NOS-I (NOS]) displays a complex transcriptional regulation, with nine alternative first exons. Exon 1c and If are the most abundant forms in the brain. A functional single nucleotide polymorphism (SNP) in exon 1c and a polymorphism in exon If, consisting of a variable number of tandem repeats (VNTR) originating short (S) and long (L) alleles, were studied in 184 patients with Alzheimer's disease (AD) and 144 gender- and age-matched controls. No differences were found for the Ex1c G-84A. The Ex1f-VNTR S allele was significantly more common in AD (55% versus 44%, P=0.009, OR = 1.52) as was the S/S genotype (28% versus 14%, P=0.008; OR=2.37). The S allele showed a highly significant interaction with the ApoE epsilon 4 allele (OR: 10.83). Therefore, short alleles of the NOS1 exon If-VNTR are likely to be susceptibility factors for AD, and interact with the epsilon 4 allele to markedly increase the AD risk.
Association of a NOS1 promoter repeat with Alzheimer's disease / D. Galimberti, E. Scarpini, E. Venturelli, A. Strobel, S. Herterich, C. Fenoglio, I. Guidi, D. Scalabrini, F. Cortini, N. Bresolin, K.P. Lesch, A. Reif. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - 29:9(2008 Sep), pp. 1359-1365.
Association of a NOS1 promoter repeat with Alzheimer's disease
E. Scarpini;N. Bresolin;
2008
Abstract
The gene encoding NOS-I (NOS]) displays a complex transcriptional regulation, with nine alternative first exons. Exon 1c and If are the most abundant forms in the brain. A functional single nucleotide polymorphism (SNP) in exon 1c and a polymorphism in exon If, consisting of a variable number of tandem repeats (VNTR) originating short (S) and long (L) alleles, were studied in 184 patients with Alzheimer's disease (AD) and 144 gender- and age-matched controls. No differences were found for the Ex1c G-84A. The Ex1f-VNTR S allele was significantly more common in AD (55% versus 44%, P=0.009, OR = 1.52) as was the S/S genotype (28% versus 14%, P=0.008; OR=2.37). The S allele showed a highly significant interaction with the ApoE epsilon 4 allele (OR: 10.83). Therefore, short alleles of the NOS1 exon If-VNTR are likely to be susceptibility factors for AD, and interact with the epsilon 4 allele to markedly increase the AD risk.File | Dimensione | Formato | |
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