Due to renewed interest in the cultivation and production of Italian Cannabis sativa L., we proposed a multi-methodological approach to explore chemically and biologically both the essential oil and the aromatic water of this plant. We reported the chemical composition in terms of cannabinoid content, volatile component, phenolic and flavonoid pattern, and color characteristics. Then, we demonstrated the ethnopharmacological relevance of this plant cultivated in Italy as a source of antioxidant compounds toward a large panel of enzymes (pancreatic lipase, -amylase, -glucosidase, and cholinesterases) and selected clinically relevant, multidrug-sensible, and multidrug-resistant microbial strains (Staphylococcus aureus, Helicobacter pylori, Candida, and Malassezia spp.), evaluating the cytotoxic effects against normal and malignant cell lines. Preliminary in vivo cytotoxicity was also performed on Galleria mellonella larvae. The results corroborate the use of this natural product as a rich source of important biologically active molecules with particular emphasis on the role exerted by naringenin, one of the most important secondary metabolites.

Chromatographic Analyses, In Vitro Biological Activities, and Cytotoxicity of Cannabis sativa L. Essential Oil: A Multidisciplinary Study / G. Zengin, L. Menghini, A. Di Sotto, R. Mancinelli, F. Sisto, S. Carradori, S. Cesa, C. Fraschetti, A. Filippi, L. Angiolella, M. Locatelli, L. Mannina, C. Ingallina, V. Puca, M. D’Antonio, R. Grande. - In: MOLECULES. - ISSN 1420-3049. - 23:12(2018 Dec).

Chromatographic Analyses, In Vitro Biological Activities, and Cytotoxicity of Cannabis sativa L. Essential Oil: A Multidisciplinary Study

F. Sisto;
2018

Abstract

Due to renewed interest in the cultivation and production of Italian Cannabis sativa L., we proposed a multi-methodological approach to explore chemically and biologically both the essential oil and the aromatic water of this plant. We reported the chemical composition in terms of cannabinoid content, volatile component, phenolic and flavonoid pattern, and color characteristics. Then, we demonstrated the ethnopharmacological relevance of this plant cultivated in Italy as a source of antioxidant compounds toward a large panel of enzymes (pancreatic lipase, -amylase, -glucosidase, and cholinesterases) and selected clinically relevant, multidrug-sensible, and multidrug-resistant microbial strains (Staphylococcus aureus, Helicobacter pylori, Candida, and Malassezia spp.), evaluating the cytotoxic effects against normal and malignant cell lines. Preliminary in vivo cytotoxicity was also performed on Galleria mellonella larvae. The results corroborate the use of this natural product as a rich source of important biologically active molecules with particular emphasis on the role exerted by naringenin, one of the most important secondary metabolites.
English
Cannabis sativa L.; chromatographic analysis; essential oil; antimicrobial activity; cancer; cell cytotoxicity; naringenin; biofilm; antioxidant activity; Galleria mellonella
Settore MED/07 - Microbiologia e Microbiologia Clinica
Articolo
Esperti anonimi
Ricerca di base
Pubblicazione scientifica
dic-2018
Molecular Diversity Preservation International (MDPI)
23
12
3266
26
Pubblicato
Periodico con rilevanza internazionale
Aderisco
info:eu-repo/semantics/article
Chromatographic Analyses, In Vitro Biological Activities, and Cytotoxicity of Cannabis sativa L. Essential Oil: A Multidisciplinary Study / G. Zengin, L. Menghini, A. Di Sotto, R. Mancinelli, F. Sisto, S. Carradori, S. Cesa, C. Fraschetti, A. Filippi, L. Angiolella, M. Locatelli, L. Mannina, C. Ingallina, V. Puca, M. D’Antonio, R. Grande. - In: MOLECULES. - ISSN 1420-3049. - 23:12(2018 Dec).
open
Prodotti della ricerca::01 - Articolo su periodico
16
262
Article (author)
si
G. Zengin, L. Menghini, A. Di Sotto, R. Mancinelli, F. Sisto, S. Carradori, S. Cesa, C. Fraschetti, A. Filippi, L. Angiolella, M. Locatelli, L. Mannin...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/605858
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